iPTMnet Report for Q9UBK8 (MTRR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBK8 / MTRR_HUMAN
Protein Name Methionine synthase reductase
Gene Name Name: MTRR
Organism Homo sapiens (Human)

PRO ID PR:Q9UBK8
DAG View
PRO Name methionine synthase reductase (human)
Definition A methionine synthase reductase that is encoded in the genome of human.
Short Label hMTRR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBK8 (MTRR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C132 Methylation IEDB 31844290
S157 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T177 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S199 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
C340 Methylation IEDB 31844290
K344 Ubiquitination PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
K598 Acetylation PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S156 Phosphorylation HPRD 20068231
S157 Phosphorylation HPRD 20068231
S171 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S164 R164 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S217 F217 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
C340 F340 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C340 Y340 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K344 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T392 A392 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S521 C521 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S523 F523 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]