iPTMnet Report for Q9UBK2 (PPARGC1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBK2 / PRGC1_HUMAN
Protein Name Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Gene Name Name: PPARGC1A
Synonyms:LEM6,PGC1,PGC1A;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBK2
DAG View
PRO Name peroxisome proliferator-activated receptor gamma coactivator 1-alpha (human)
Definition A peroxisome proliferator-activated receptor gamma coactivator 1-alpha that is encoded in the genome of human.
Short Label hPPARGC1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBK2 (PPARGC1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T178 Phosphorylation PRO   Signor 17609368
T178 Phosphorylation Q13131 (PRKAA1) Signor 17609368
S208 Phosphorylation PhosphoSitePlus
K224 Methylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
T263 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 11741533
T263 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11741533
S266 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 11741533
S266 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11741533
S273 Phosphorylation PhosphoSitePlus
K278 Acetylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
T299 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 11741533
T299 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11741533
S313 Phosphorylation PhosphoSitePlus
K347 Acetylation PhosphoSitePlus
K360 Acetylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PRO
R548 Methylation PhosphoSitePlus
R570 Methylation PhosphoSitePlus
S571 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 17554339, 19915805
S571 Phosphorylation P31749 (AKT1) neXtProt   Signor 17554339
S571 Phosphorylation P31751 (AKT2) Signor 17554339
S616 Phosphorylation PhosphoSitePlus
Y634 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
R665 Methylation PhosphoSitePlus
R667 Methylation PhosphoSitePlus
R669 Methylation PhosphoSitePlus
Y717 Phosphorylation PhosphoSitePlus
T721 Phosphorylation PhosphoSitePlus
Y722 Phosphorylation PhosphoSitePlus
R753 Methylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
K779 Methylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T263 Phosphorylation HPRD 11741533
T263 Phosphorylation Q16539 (MAPK14) HPRD 11741533
S266 Phosphorylation HPRD 11741533
S266 Phosphorylation Q16539 (MAPK14) HPRD 11741533
T299 Phosphorylation HPRD 11741533
T299 Phosphorylation Q16539 (MAPK14) HPRD 11741533


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048855 (hPPARGC1A/Phos:1) pT178,pS539 PRO
PR:000048856 (hPPARGC1A/Phos:2) pT263,pS266,pT299 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S208 L208 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S246 P246 Biomuta DOID:1319 / brain cancer [ cosmic ]
S246 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S266 L266 Biomuta DOID:1324 / lung cancer [ cosmic ]
S273 F273 Biomuta DOID:4159 / skin cancer [ cosmic ]
S285 K285 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S313 F313 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S313 Y313 Biomuta DOID:363 / uterine cancer [ icgc ]
K442 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K464 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K480 T480 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R548 G548 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R570 K570 Biomuta DOID:4159 / skin cancer [ cosmic ]
S571 F571 Biomuta DOID:4159 / skin cancer [ cosmic ]
S616 Y616 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y634 H634 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y634 N634 Biomuta DOID:1324 / lung cancer [ cosmic ]
S636 N636 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S636 R636 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R665 M665 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R667 G667 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R669 S669 Biomuta DOID:1319 / brain cancer [ icgc ]
R753 H753 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R753 C753 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S768 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K777 M777 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K777 T777 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S782 F782 Biomuta DOID:4159 / skin cancer [ cosmic ]