Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9UBI6 / GBG12_HUMAN
Protein Name Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor
Gene Name Name: GNG12
Organism Homo sapiens (Human)

DAG View
PRO Name guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (human)
Definition A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 that is encoded in the genome of human.
Short Label hGNG12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9UBI6 (GNG12) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 Phosphorylation HPRD   PhosphoSitePlus 20068231, 7493986
K4 Ubiquitination PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation HPRD   PhosphoSitePlus 20068231
T8 Phosphorylation HPRD   PhosphoSitePlus 20068231
S26 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
K34 Ubiquitination PhosphoSitePlus
S41 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
Y42 Phosphorylation HPRD   PhosphoSitePlus 17081983
C43 S-Nitrosylation dbSNO 2212679
S49 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 24275569
K64 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 F2 Biomuta DOID:1324 / lung cancer [ tcga ]
S2 Y2 Biomuta DOID:3571 / liver cancer [ icgc ]
S7 T7 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S7 I7 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K34 N34 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]