iPTMnet Report for Q9UBE8 (NLK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBE8 / NLK_HUMAN
Protein Name Serine/threonine-protein kinase NLK
Gene Name Name: NLK
Synonyms:LAK1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBE8
DAG View
PRO Name serine/threonine-protein kinase NLK (human)
Definition A serine/threonine-protein kinase NLK that is encoded in the genome of human.
Short Label hNLK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBE8 (NLK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S274 Phosphorylation PhosphoSitePlus
T298 Phosphorylation Q9UBE8 (NLK) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 23186163, 18077418, ...19651622, 21118996, 19690332, 32620751
S315 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus   UniProt 19369195


Q9UBE8 (NLK) as PTM Enzyme



Substrate Site Score Source PMID
P40763 (STAT3) S727 neXtProt   Signor 17563747, 15764709, 15004007
P46937 (YAP1) S128 RLIMS-P+ 27979971
P49023 (PXN) S126 neXtProt 19840224
Q12778 (FOXO1) S329 PhosphoSitePlus 20061393
Q13485 (SMAD4) T9 neXtProt   PhosphoSitePlus 19690946
Q13485 (SMAD4) S138 neXtProt   PhosphoSitePlus 19690946
Q15047 (SETDB1) T976 neXtProt 17952062
Q8N122 (RPTOR) S863 PhosphoSitePlus 26588989
Q9NQB0 (TCF7L2) T201 neXtProt   PhosphoSitePlus   Signor 12556497
Q9NQB0 (TCF7L2) T212 neXtProt   PhosphoSitePlus   Signor 12556497
Q9UBE8 (NLK) T298 UniProt 19369195
Q9UJU2 (LEF1) S132 PhosphoSitePlus 22373574
Q9UJU2-1 (LEF1) T155 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12556497, 22373574
Q9UJU2 (LEF1) S166 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12556497, 22373574
Q9UJU2 (LEF1) S200 PhosphoSitePlus 22373574
Q9UJU2 (LEF1) T265 PhosphoSitePlus 22373574


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S315 N315 Biomuta [ cosmic ]
T367 S367 Biomuta DOID:1324 / lung cancer [ cosmic ]
S385 F385 Biomuta DOID:363 / uterine cancer [ icgc ]
K419 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K469 N469 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]