iPTMnet Report for Q9UBE0 (SAE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBE0 / SAE1_HUMAN
Protein Name SUMO-activating enzyme subunit 1
Gene Name Name: SAE1
Synonyms:AOS1,SUA1,UBLE1A;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBE0
DAG View
PRO Name SUMO-activating enzyme subunit 1 (human)
Definition A SUMO-activating enzyme subunit 1 that is encoded in the genome of human.
Short Label hSAE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBE0 (SAE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
V2 Acetylation UniProt 19413330, 25489052
S12 Phosphorylation PhosphoSitePlus   UniProt 23186163
R24 Methylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K109 Sumoylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
S185 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T194 Phosphorylation PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K195 Sumoylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
Y240 Phosphorylation IEDB 35494241
Y262 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
C303 Methylation IEDB 31844290
K335 Ubiquitination PhosphoSitePlus
C342 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 19664994
S185 Phosphorylation HPRD 17525332, 18077418
Site PTM Type PTM Enzyme Score Source PMID
S288 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K148 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K195 N195 Biomuta DOID:1324 / lung cancer [ cosmic ]
K208 E208 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K210 N210 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y240 F240 Biomuta DOID:1324 / lung cancer [ cosmic ]
S266 C266 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]