iPTMnet Report for Q9UBD5 (ORC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBD5 / ORC3_HUMAN
Protein Name Origin recognition complex subunit 3
Gene Name Name: ORC3
Synonyms:LATHEO,ORC3L;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBD5
DAG View
PRO Name origin recognition complex subunit 3 (human)
Definition An origin recognition complex subunit 3 that is encoded in the genome of human.
Short Label hORC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBD5 (ORC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K21 Acetylation PhosphoSitePlus
S23 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y29 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K145 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S208 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
Y375 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
T470 Phosphorylation IEDB 32387766
C475 Methylation IEDB 31844290
K480 Ubiquitination PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S516 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K523 Ubiquitination PhosphoSitePlus
Y527 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K543 Acetylation PhosphoSitePlus
C561 Methylation IEDB 31844290
T572 Phosphorylation IEDB 32387766
Y607 Phosphorylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 18669648, 20068231
T205 Phosphorylation HPRD 20068231
S208 Phosphorylation HPRD 17525332
S424 Phosphorylation HPRD 20068231
S516 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 18669648, 20068231
T205 Phosphorylation HPRD 20068231
S208 Phosphorylation HPRD 17525332
S424 Phosphorylation HPRD 20068231
S503 Phosphorylation PhosphoSitePlus
T508 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 C23 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y47 F47 Biomuta DOID:1612 / breast cancer [ cosmic ]
S56 Y56 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K145 N145 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K163 T163 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S424 Y424 Biomuta DOID:363 / uterine cancer [ icgc ]
K492 N492 Biomuta DOID:1324 / lung cancer [ cosmic ]
S503 N503 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K508 N508 Biomuta [ cosmic ]
K537 N537 Biomuta DOID:1324 / lung cancer [ icgc ]
C561 Y561 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T572 S572 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S685 F685 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]