iPTMnet Report for Q9UBC3 (DNMT3B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBC3 / DNM3B_HUMAN
Protein Name DNA (cytosine-5)-methyltransferase 3B
Gene Name Name: DNMT3B
Organism Homo sapiens (Human)

PRO ID PR:Q9UBC3
DAG View
PRO Name DNA (cytosine-5)-methyltransferase 3B (human)
Definition A DNA (cytosine-5)-methyltransferase 3B that is encoded in the genome of human.
Short Label hDNMT3B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBC3 (DNMT3B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S51 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus   UniProt 21406692
T96 Phosphorylation PhosphoSitePlus   UniProt 21406692
S98 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus   UniProt 21406692
T105 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus   UniProt 21406692
S112 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S195 Phosphorylation PhosphoSitePlus   UniProt 21406692
S202 Phosphorylation PhosphoSitePlus   UniProt 21406692
S209 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S270 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
Y588 Phosphorylation PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
Y815 Phosphorylation PhosphoSitePlus
T816 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
R823 Methylation PhosphoSitePlus
R826 Methylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation HPRD 19664995
S136 Phosphorylation HPRD 19651622, 19664995, 20068231
S202 Phosphorylation HPRD 19664995
S209 Phosphorylation HPRD 19664995
T353 Phosphorylation HPRD 20068231
T383 Phosphorylation HPRD 19664994, 19664995
S387 Phosphorylation HPRD 19664995
Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation HPRD 19664995
S136 Phosphorylation HPRD 19651622, 19664995, 20068231
S202 Phosphorylation HPRD 19664995
S209 Phosphorylation HPRD 19664995
T363 Phosphorylation HPRD 19664994, 19664995
S367 Phosphorylation HPRD 19664995
Site PTM Type PTM Enzyme Score Source PMID
S51 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S82 Phosphorylation HPRD 19664995
S98 Phosphorylation PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S136 Phosphorylation HPRD 19651622, 19664995, 20068231
S202 Phosphorylation HPRD 19664995
S209 Phosphorylation HPRD 19664995
T363 Phosphorylation HPRD   PhosphoSitePlus 19664994, 19664995
S367 Phosphorylation HPRD   PhosphoSitePlus 19664995
Y732 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S94 Phosphorylation HPRD 19664995
S148 Phosphorylation HPRD 19651622, 19664995, 20068231
S214 Phosphorylation HPRD 19664995
S221 Phosphorylation HPRD 19664995
T375 Phosphorylation HPRD   PhosphoSitePlus 19664994, 19664995
S379 Phosphorylation HPRD   PhosphoSitePlus 19664995
Site PTM Type PTM Enzyme Score Source PMID
S100 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S51 P51 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S51 T51 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S52 R52 Biomuta [ cosmic ]
S53 L53 Biomuta DOID:4159 / skin cancer [ cosmic ]
S103 T103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S112 F112 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S113 T113 Biomuta DOID:263 / kidney cancer [ cosmic ]
S113 I113 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S136 Y136 Biomuta DOID:4159 / skin cancer [ cosmic ]
S148 Y148 Biomuta DOID:4159 / skin cancer [ cosmic ]
S195 I195 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S195 R195 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S270 C270 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y303 H303 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T353 M353 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
K562 R562 Biomuta [ cosmic ]
Y588 C588 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S711 * Biomuta DOID:263 / kidney cancer [ cosmic ]
Y732 C732 Biomuta DOID:4159 / skin cancer [ cosmic ]
S780 W780 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S780 L780 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
Y815 C815 Biomuta DOID:4159 / skin cancer [ cosmic ]
T816 I816 Biomuta DOID:4159 / skin cancer [ cosmic ]
R823 C823 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R826 H826 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:363 / uterine cancer [ icgc, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]