iPTMnet Report for Q9UBC2 (EPS15L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBC2 / EP15R_HUMAN
Protein Name Epidermal growth factor receptor substrate 15-like 1
Gene Name Name: EPS15L1
Synonyms:EPS15R;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBC2
DAG View
PRO Name epidermal growth factor receptor substrate 15-like 1 (human)
Definition An epidermal growth factor receptor substrate 15-like 1 that is encoded in the genome of human.
Short Label hEPS15L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBC2 (EPS15L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
Y30 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T113 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S229 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 24275569
S235 Phosphorylation PhosphoSitePlus
S238 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T239 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S241 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 15144186
S244 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 15144186, ...18669648, 19690332
S246 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
S253 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S255 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...15144186, 18669648, 19690332, 20068231
S259 Phosphorylation PhosphoSitePlus   UniProt 23186163
K261 Ubiquitination PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S371 Phosphorylation PhosphoSitePlus   UniProt 24275569
S372 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus   UniProt 23186163
S377 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K384 Ubiquitination PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
T418 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y564 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
T577 Phosphorylation PhosphoSitePlus   UniProt 19690332
S583 Phosphorylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K602 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus   UniProt 24275569
S672 Phosphorylation PhosphoSitePlus   UniProt 23186163
K679 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus   UniProt 23186163
K701 Ubiquitination PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
S708 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S712 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus   UniProt 23186163
S718 Phosphorylation PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus   UniProt 24275569
T776 Phosphorylation PhosphoSitePlus
K782 Acetylation PhosphoSitePlus
K783 Acetylation PhosphoSitePlus
S793 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
T797 Phosphorylation PhosphoSitePlus   UniProt 19690332
K828 Ubiquitination PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K838 Ubiquitination PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S49 Phosphorylation HPRD 20068231
T106 Phosphorylation HPRD 20058876, 20068231
S107 Phosphorylation HPRD 17081983, 20068231
S108 Phosphorylation HPRD 20058876, 17081983, 20068231
S229 Phosphorylation HPRD 19413330, 17322306, 16964243, ...18767875, 20058876, 19664995, 18452278, 19651622, 18669648, 20068231
S238 Phosphorylation HPRD 19413330, 18669648, 20068231
T239 Phosphorylation HPRD 18669648, 20068231
S241 Phosphorylation HPRD 18669648, 15144186
S244 Phosphorylation HPRD 18669648, 15144186, 20068231
S247 Phosphorylation HPRD 20068231
T251 Phosphorylation HPRD 18491316
S253 Phosphorylation HPRD 18669648, 20068231, 18452278
S255 Phosphorylation HPRD 19413330, 17322306, 18491316, ...20058876, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
T366 Phosphorylation HPRD 19664994, 17924679
S371 Phosphorylation HPRD 17924679
S374 Phosphorylation HPRD 20068231, 17924679
S377 Phosphorylation HPRD 20068231
T528 Phosphorylation HPRD 20068231
S593 Phosphorylation HPRD 20068231
S708 Phosphorylation HPRD 18669648, 20068231
S793 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
K851 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S593 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y74 C74 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T106 I106 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S171 T171 Biomuta DOID:1612 / breast cancer [ cosmic ]
T239 M239 Biomuta DOID:1612 / breast cancer [ cosmic ]
S244 I244 Biomuta DOID:363 / uterine cancer [ icgc ]
S244 N244 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S255 F255 Biomuta DOID:3571 / liver cancer [ cosmic ]
S259 R259 Biomuta DOID:3571 / liver cancer [ cosmic ]
S362 L362 Biomuta DOID:1781 / thyroid cancer [ icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S371 N371 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S377 C377 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S548 F548 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S553 I553 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S560 I560 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T577 A577 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S593 G593 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T612 A612 Biomuta DOID:363 / uterine cancer [ icgc ]
K638 R638 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K664 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K680 T680 Biomuta DOID:363 / uterine cancer [ icgc ]
S689 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S689 L689 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K701 R701 Biomuta DOID:184 / bone cancer [ cosmic ]
S707 C707 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S708 N708 Biomuta DOID:363 / uterine cancer [ icgc ]
S712 L712 Biomuta [ cosmic ] DOID:4362 / cervical cancer [ icgc ]
S717 F717 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
K782 E782 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K838 R838 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic ]