iPTMnet Report for Q9P2T1 (GMPR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2T1 / GMPR2_HUMAN
Protein Name GMP reductase 2
Gene Name Name: GMPR2
Organism Homo sapiens (Human)

PRO ID PR:Q9P2T1
DAG View
PRO Name GMP reductase 2 (human)
Definition A GMP reductase 2 that is encoded in the genome of human.
Short Label hGMPR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2T1 (GMPR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
C68 Methylation IEDB 31844290
C127 Methylation IEDB 31844290
S184 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
K291 Acetylation PhosphoSitePlus   UniProt 19608861
K291 Ubiquitination PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
Y318 Phosphorylation PhosphoSitePlus
C348 S-Nitrosylation dbSNO 26338901


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K20 R20 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S26 F26 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y285 H285 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]