iPTMnet Report for Q9P2K8 (EIF2AK4)
Protein Information
UniProt AC / UniProt ID | Q9P2K8 / E2AK4_HUMAN |
Protein Name | eIF-2-alpha kinase GCN2 |
Gene Name | Name: EIF2AK4 Synonyms:GCN2,KIAA1338; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9P2K8 |
PRO Name | eIF-2-alpha kinase GCN2 (human) |
Definition | An eIF-2-alpha kinase GCN2 that is encoded in the genome of human. |
Short Label | hEIF2AK4 |
Category | organism-gene |
Q9P2K8 (EIF2AK4) as Substrate
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
R5 | Methylation | score1 | PhosphoSitePlus | |||
S102 | Phosphorylation | score1 | PhosphoSitePlus | |||
S205 | Phosphorylation | score1 | PhosphoSitePlus | |||
S207 | Phosphorylation | score1 | PhosphoSitePlus | |||
S230 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 21406692, 23186163, ...18669648, 20068231 | ||
Y253 | Phosphorylation | score1 | PhosphoSitePlus | |||
S254 | Phosphorylation | score1 | PhosphoSitePlus | |||
S261 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y269 | Phosphorylation | score1 | PhosphoSitePlus | |||
S467 | Phosphorylation | score1 | PhosphoSitePlus | |||
K474 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y500 | Phosphorylation | score1 | PhosphoSitePlus | |||
S551 | Phosphorylation | score1 | PhosphoSitePlus | |||
S555 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y560 | Phosphorylation | score1 | PhosphoSitePlus | |||
S572 | Phosphorylation | score1 | PhosphoSitePlus | |||
K606 | Acetylation | score1 | PhosphoSitePlus | |||
K610 | Ubiquitination | score1 | PhosphoSitePlus | |||
K619 | Ubiquitination | score1 | PhosphoSitePlus | |||
K634 | Ubiquitination | score1 | PhosphoSitePlus | |||
T667 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 23186163, 17081983, ...19369195, 17192257, 20068231 | ||
S672 | Phosphorylation | score1 | PhosphoSitePlus | |||
S770 | Phosphorylation | score1 | PhosphoSitePlus | |||
K850 | Ubiquitination | score1 | PhosphoSitePlus | |||
T871 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T899 | Phosphorylation | Q9P2K8 (EIF2AK4) | score4 | neXtProt PhosphoSitePlus RLIMS-P | 25589675, 26709701, 9528799, ...29383104, 21849502, 33289483 | |
T904 | Phosphorylation | Q9P2K8 (EIF2AK4) | score3 | neXtProt | 9528799, 21849502 | |
S928 | Phosphorylation | score1 | PhosphoSitePlus | |||
T991 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1085 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1135 | Methylation | score1 | PhosphoSitePlus | |||
K1135 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1259 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K1489 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1627 | Ubiquitination | score1 | PhosphoSitePlus |
Q9P2K8 (EIF2AK4) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
P05198 (EIF2S1) | S52 | score4 | neXtProt Signor | 15355306, 15684420, 10504407, ...32513922 | |
P56192 (MARS1) | S229 | score2 | PhosphoSitePlus | 22106287 | |
P56192 (MARS1) | S472 | score2 | PhosphoSitePlus | 22106287 | |
P56192 (MARS1) | S662 | score3 | PhosphoSitePlus Signor | 22106287 | |
Q9P2K8 (EIF2AK4) | T899 | score3 | neXtProt | 9528799, 21849502 | |
Q9P2K8 (EIF2AK4) | T904 | score3 | neXtProt | 9528799, 21849502 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S261 | F261 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S551 | N551 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S551 | C551 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T904 | S904 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S1040 | P1040 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
T1085 | A1085 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K1135 | E1135 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K1627 | E1627 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
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