iPTMnet Report for Q9P2J5 (LARS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2J5 / SYLC_HUMAN
Protein Name Leucine--tRNA ligase, cytoplasmic
Gene Name Name: LARS1
Synonyms:KIAA1352,LARS;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2J5
DAG View
PRO Name leucine--tRNA ligase, cytoplasmic (human)
Definition A leucine--tRNA ligase, cytoplasmic that is encoded in the genome of human.
Short Label hLARS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2J5 (LARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K45 Acetylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
C70 Methylation IEDB 31844290
K82 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
C100 Methylation IEDB 31844290
S145 O-Glycosylation GlyGen 23301498, 16408927, 35138101, ...30379171, 34725712, 25367160, 29351928, 34019948, 32870666, 32119511, 35614056, 28510447, 33465208
K155 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus   UniProt 23186163
K173 Ubiquitination PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
T238 O-Glycosylation GlyGen 23301498, 16408927, 35138101, ...30379171, 34725712, 25367160, 29351928, 34019948, 32870666, 32119511, 35614056, 28510447, 33465208
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S363 O-Glycosylation GlyGen 23301498, 16408927, 35138101, ...30379171, 34725712, 25367160, 29351928, 34019948, 32870666, 32119511, 35614056, 28510447, 33465208
T367 Phosphorylation PhosphoSitePlus
K381 Acetylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
C446 Methylation IEDB 31844290
K459 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
C522 Methylation IEDB 31844290
K540 Acetylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
Y637 Phosphorylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
T648 Phosphorylation PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
Y666 Phosphorylation PhosphoSitePlus
T702 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus   UniProt 23186163
T721 Phosphorylation PhosphoSitePlus
T726 Phosphorylation IEDB 32387766
T728 Phosphorylation PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
R795 Methylation PhosphoSitePlus
K807 Ubiquitination PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K822 Ubiquitination PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
C863 Methylation IEDB 31844290
C867 Methylation IEDB 31844290
K914 Ubiquitination PhosphoSitePlus
K921 Acetylation PhosphoSitePlus
K923 Acetylation PhosphoSitePlus
K924 Acetylation PhosphoSitePlus
K927 Ubiquitination PhosphoSitePlus
K932 Ubiquitination PhosphoSitePlus
Y944 Phosphorylation PhosphoSitePlus
K965 Ubiquitination PhosphoSitePlus
K970 Ubiquitination PhosphoSitePlus
S974 O-Glycosylation GlyGen 23301498, 16408927, 35138101, ...30379171, 34725712, 25367160, 29351928, 34019948, 32870666, 32119511, 35614056, 28510447, 33465208
S978 O-Glycosylation GlyGen 23301498, 16408927, 35138101, ...30379171, 34725712, 25367160, 29351928, 34019948, 32870666, 32119511, 35614056, 28510447, 33465208
K983 Ubiquitination PhosphoSitePlus
Y985 Phosphorylation PhosphoSitePlus
K988 Ubiquitination PhosphoSitePlus
K1002 Ubiquitination PhosphoSitePlus
S1042 O-Glycosylation GlyGen 23301498, 16408927, 35138101, ...30379171, 34725712, 25367160, 29351928, 34019948, 32870666, 32119511, 35614056, 28510447, 33465208
S1042 Phosphorylation PhosphoSitePlus
K1047 Ubiquitination PhosphoSitePlus
K1056 Ubiquitination PhosphoSitePlus
C1093 Methylation IEDB 31844290
K1133 Ubiquitination PhosphoSitePlus
Y1135 Phosphorylation PhosphoSitePlus
K1138 Ubiquitination PhosphoSitePlus
S1153 O-Glycosylation GlyGen 23301498, 16408927, 35138101, ...30379171, 34725712, 25367160, 29351928, 34019948, 32870666, 32119511, 35614056, 28510447, 33465208
K1154 Ubiquitination PhosphoSitePlus
Y1173 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S718 Phosphorylation HPRD 17924679
T721 Phosphorylation HPRD 17924679
T728 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K15 N15 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S35 F35 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K43 N43 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K43 R43 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K45 M45 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K82 N82 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K82 T82 Biomuta DOID:363 / uterine cancer [ cosmic ]
K82 R82 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K173 R173 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K173 T173 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K173 N173 Biomuta DOID:4159 / skin cancer [ cosmic ]
K173 E173 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T238 I238 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y264 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K341 Q341 Biomuta DOID:363 / uterine cancer [ icgc ]
S363 P363 Biomuta DOID:4159 / skin cancer [ cosmic ]
S363 C363 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C446 F446 Biomuta DOID:4159 / skin cancer [ cosmic ]
K541 Q541 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K716 N716 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T721 K721 Biomuta DOID:3571 / liver cancer [ cosmic ]
R795 K795 Biomuta DOID:1319 / brain cancer [ cosmic ]
C863 R863 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K914 N914 Biomuta DOID:363 / uterine cancer [ icgc ]
K921 E921 Biomuta DOID:1324 / lung cancer [ cosmic ]
K924 N924 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K932 T932 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1135 H1135 Biomuta DOID:9256 / colorectal cancer [ cosmic ]