iPTMnet Report for Q9P2I0 (CPSF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2I0 / CPSF2_HUMAN
Protein Name Cleavage and polyadenylation specificity factor subunit 2
Gene Name Name: CPSF2
Synonyms:CPSF100,KIAA1367;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2I0
DAG View
PRO Name cleavage and polyadenylation specificity factor subunit 2 (human)
Definition A cleavage and polyadenylation specificity factor subunit 2 that is encoded in the genome of human.
Short Label hCPSF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2I0 (CPSF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C20 Methylation IEDB 31844290
C34 Methylation IEDB 31844290
T87 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
Y395 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
K398 Ubiquitination PhosphoSitePlus
S419 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18452278, 19651622, 18669648, 24275569, 19690332
S420 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18452278, 19651622, 18669648, 24275569, 19690332
S423 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18452278, 19651622, 18669648, 24275569, 19690332
K438 Ubiquitination PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S460 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...36240223, 35008409
S460 Phosphorylation PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
Y476 Phosphorylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
C522 Methylation IEDB 31844290
K551 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
R609 Methylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
S660 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
K680 Acetylation PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
Y776 Phosphorylation PhosphoSitePlus
Y779 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K290 T290 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K472 E472 Biomuta DOID:3571 / liver cancer [ cosmic ]
K499 T499 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R609 K609 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]