iPTMnet Report for Q9P2G9 (KLHL8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2G9 / KLHL8_HUMAN
Protein Name Kelch-like protein 8
Gene Name Name: KLHL8
Synonyms:KIAA1378;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2G9
DAG View
PRO Name kelch-like protein 8 (human)
Definition A kelch-like protein 8 that is encoded in the genome of human.
Short Label hKLHL8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2G9 (KLHL8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K9 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
T551 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:363 / uterine cancer [ icgc ]
K28 N28 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
K392 R392 Biomuta DOID:363 / uterine cancer [ icgc ]
K392 T392 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K491 E491 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T551 K551 Biomuta DOID:263 / kidney cancer [ cosmic ]