iPTMnet Report for Q9P2F8 (SIPA1L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2F8 / SI1L2_HUMAN
Protein Name Signal-induced proliferation-associated 1-like protein 2
Gene Name Name: SIPA1L2
Synonyms:KIAA1389;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2F8
DAG View
PRO Name signal-induced proliferation-associated 1-like protein 2 (human)
Definition A signal-induced proliferation-associated 1-like protein 2 that is encoded in the genome of human.
Short Label hSIPA1L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2F8 (SIPA1L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
Y33 Phosphorylation PhosphoSitePlus
S148 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 18220336
S160 Phosphorylation PhosphoSitePlus
S162 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T165 Phosphorylation phospho.ELM 18669648
S194 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
Y475 Phosphorylation PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
Y487 Phosphorylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
T672 Phosphorylation PhosphoSitePlus
K766 Ubiquitination PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
Y808 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K1046 Ubiquitination PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
T1065 Phosphorylation PhosphoSitePlus
T1071 Phosphorylation PhosphoSitePlus
S1081 Phosphorylation PhosphoSitePlus
T1086 Phosphorylation PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
S1193 Phosphorylation PhosphoSitePlus
K1195 Ubiquitination PhosphoSitePlus
S1244 Phosphorylation PhosphoSitePlus
Y1257 Phosphorylation PhosphoSitePlus
T1276 Phosphorylation PhosphoSitePlus
S1286 Phosphorylation PhosphoSitePlus
S1304 Phosphorylation PhosphoSitePlus
Y1314 Phosphorylation PhosphoSitePlus
Y1387 Phosphorylation PhosphoSitePlus
S1461 Phosphorylation PhosphoSitePlus   UniProt 19369195, 19690332
S1472 Phosphorylation PhosphoSitePlus
Y1474 Phosphorylation PhosphoSitePlus
S1478 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186, 18220336
T1486 Phosphorylation PhosphoSitePlus
S1488 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1491 O-Glycosylation GlyGen 30620550
S1499 Phosphorylation PhosphoSitePlus
S1520 Phosphorylation PhosphoSitePlus
T1521 Phosphorylation PhosphoSitePlus
T1522 Phosphorylation PhosphoSitePlus
Y1525 Phosphorylation PhosphoSitePlus
S1527 Phosphorylation PhosphoSitePlus
S1538 Phosphorylation PhosphoSitePlus
S1541 Phosphorylation PhosphoSitePlus
S1549 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1552 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1554 Phosphorylation PhosphoSitePlus
K1556 Ubiquitination PhosphoSitePlus
K1558 Ubiquitination PhosphoSitePlus
S1611 Phosphorylation PhosphoSitePlus
S1650 Phosphorylation PhosphoSitePlus
S1652 Phosphorylation PhosphoSitePlus
K1679 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S148 Phosphorylation HPRD 18669648, 20068231
S162 Phosphorylation HPRD 18669648, 18452278
T165 Phosphorylation HPRD 18669648, 17081983
S241 Phosphorylation HPRD 20068231
S1029 Phosphorylation HPRD 18669648, 20068231
Y1257 Phosphorylation HPRD 18491316
S1461 Phosphorylation HPRD 19664995
S1478 Phosphorylation HPRD 15570572, 19664995
S1488 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995
S1650 Phosphorylation HPRD 20068231
S1652 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S160 I160 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S160 R160 Biomuta DOID:263 / kidney cancer [ cosmic ]
K223 N223 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S379 F379 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T671 A671 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K793 T793 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S1029 L1029 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1046 E1046 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1065 M1065 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T1065 A1065 Biomuta DOID:363 / uterine cancer [ icgc ]
T1086 M1086 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S1472 L1472 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1474 C1474 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1474 H1474 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1478 P1478 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T1521 S1521 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1538 I1538 Biomuta DOID:363 / uterine cancer [ icgc ]
S1554 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K1556 E1556 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K1558 E1558 Biomuta DOID:9256 / colorectal cancer [ cosmic ]