iPTMnet Report for Q9P2E8 (MARCHF4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2E8 / MARH4_HUMAN
Protein Name E3 ubiquitin-protein ligase MARCHF4 precursor
Gene Name Name: MARCHF4
Synonyms:KIAA1399,MARCH4,RNF174;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2E8
DAG View
PRO Name E3 ubiquitin-protein ligase MARCHF4 (human)
Definition An E3 ubiquitin-protein ligase MARCHF4 that is encoded in the genome of human.
Short Label hMARCHF4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2E8 (MARCHF4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R164 Methylation PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R164 S164 Biomuta DOID:1324 / lung cancer [ cosmic ]
R164 C164 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S218 C218 Biomuta DOID:1324 / lung cancer [ cosmic ]
S218 N218 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S346 Y346 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S346 F346 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]