iPTMnet Report for Q9P2D1 (CHD7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2D1 / CHD7_HUMAN
Protein Name Chromodomain-helicase-DNA-binding protein 7
Gene Name Name: CHD7
Synonyms:KIAA1416;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2D1
DAG View
PRO Name chromodomain-helicase-DNA-binding protein 7 (human)
Definition A chromodomain-helicase-DNA-binding protein 7 that is encoded in the genome of human.
Short Label hCHD7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2D1 (CHD7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y75 Phosphorylation PhosphoSitePlus
R148 Methylation PhosphoSitePlus   UniProt 24129315
R195 Methylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
R209 Methylation PhosphoSitePlus
R250 Methylation IEDB 27503676
R346 Methylation IEDB 27503676
R414 Methylation PhosphoSitePlus
R448 Methylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
K565 Acetylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus   UniProt 21406692
T689 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus   UniProt 21406692
T730 Phosphorylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
T786 Phosphorylation PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
K1116 Ubiquitination PhosphoSitePlus
K1177 Ubiquitination PhosphoSitePlus
K1183 Ubiquitination PhosphoSitePlus
K1196 Sumoylation PhosphoSitePlus
T1204 Phosphorylation PhosphoSitePlus
Y1217 Phosphorylation PhosphoSitePlus
Y1218 Phosphorylation PhosphoSitePlus
T1227 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K1250 Ubiquitination PhosphoSitePlus
Y1256 Phosphorylation PhosphoSitePlus
K1297 Ubiquitination PhosphoSitePlus
R1308 Methylation PhosphoSitePlus
R1317 Methylation PhosphoSitePlus
R1359 Methylation PhosphoSitePlus
K1427 Ubiquitination PhosphoSitePlus
K1431 Ubiquitination PhosphoSitePlus
K1436 Ubiquitination PhosphoSitePlus
T1449 Phosphorylation PhosphoSitePlus
S1456 Phosphorylation PhosphoSitePlus
K1458 Ubiquitination PhosphoSitePlus
K1466 Ubiquitination PhosphoSitePlus
K1511 Ubiquitination PhosphoSitePlus
K1533 Ubiquitination PhosphoSitePlus
T1555 Phosphorylation PhosphoSitePlus
S1566 Phosphorylation PhosphoSitePlus
S1577 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1581 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1583 Phosphorylation PhosphoSitePlus
S1793 Phosphorylation PhosphoSitePlus
T1862 Phosphorylation PhosphoSitePlus
S1874 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S1876 Phosphorylation PhosphoSitePlus
S2010 O-Glycosylation GlyGen 30379171, 35289036, 29351928
S2141 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T2153 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2229 Phosphorylation PhosphoSitePlus
S2231 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2233 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2237 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2251 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S2254 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S2255 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S2272 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2275 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2277 Phosphorylation PhosphoSitePlus
T2278 Phosphorylation PhosphoSitePlus
Y2349 Phosphorylation PhosphoSitePlus
T2350 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T2352 Phosphorylation PhosphoSitePlus
S2356 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S2395 Phosphorylation PhosphoSitePlus   UniProt 20068231
K2446 Ubiquitination PhosphoSitePlus
S2471 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T2472 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 18847512, 20068231
S2475 O-Glycosylation GlyGen 30379171, 35289036, 29351928
T2492 Phosphorylation PhosphoSitePlus
S2501 Phosphorylation PhosphoSitePlus
T2532 Phosphorylation PhosphoSitePlus
S2533 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S2535 Phosphorylation PhosphoSitePlus   UniProt 21406692
T2542 Phosphorylation PhosphoSitePlus
T2551 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T2554 Phosphorylation PhosphoSitePlus
S2559 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...15302935, 18669648, 19690332, 20068231
Y2601 Phosphorylation PhosphoSitePlus
Y2608 Phosphorylation PhosphoSitePlus
S2619 Phosphorylation PhosphoSitePlus   UniProt 20068231
T2640 Phosphorylation PhosphoSitePlus
S2698 Phosphorylation PhosphoSitePlus
T2705 Phosphorylation PhosphoSitePlus
S2715 Phosphorylation PhosphoSitePlus
T2952 Phosphorylation PhosphoSitePlus
S2956 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S2961 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
T2965 Phosphorylation phospho.ELM 18669648
S2969 Phosphorylation PhosphoSitePlus
S2983 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S637 Phosphorylation HPRD 20068231
S708 Phosphorylation HPRD 20068231
S725 Phosphorylation HPRD 18452278
T730 Phosphorylation HPRD 18452278
S734 Phosphorylation HPRD 18452278
T786 Phosphorylation HPRD 18452278
S1577 Phosphorylation HPRD 20068231
S1581 Phosphorylation HPRD 20068231
T1635 Phosphorylation HPRD 20068231
S1793 Phosphorylation HPRD 20068231
S1874 Phosphorylation HPRD 19413330, 19651622, 20068231, ...18452278
S2141 Phosphorylation HPRD 18669648
T2153 Phosphorylation HPRD 18669648
S2251 Phosphorylation HPRD 20068231
S2254 Phosphorylation HPRD 17525332, 20068231, 18452278
S2255 Phosphorylation HPRD 17525332, 18452278
S2272 Phosphorylation HPRD 18452278
S2275 Phosphorylation HPRD 18452278
S2277 Phosphorylation HPRD 20068231
T2350 Phosphorylation HPRD 18669648, 20068231
S2356 Phosphorylation HPRD 18669648, 20068231
S2395 Phosphorylation HPRD 20068231
T2472 Phosphorylation HPRD 20068231
S2533 Phosphorylation HPRD 18669648, 20068231
T2551 Phosphorylation HPRD 18669648, 20068231, 18452278
S2559 Phosphorylation HPRD 19413330, 20058876, 19664994, ...19664995, 19651622, 18669648, 20068231
S2619 Phosphorylation HPRD 20068231
S2956 Phosphorylation HPRD 19651622, 20068231, 18452278
S2961 Phosphorylation HPRD 20068231, 18452278
T2965 Phosphorylation HPRD 18669648
S2969 Phosphorylation HPRD 18452278
S2983 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y75 H75 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R195 C195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R195 H195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R250 C250 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S782 F782 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1116 E1116 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1196 N1196 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1227 A1227 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R1317 H1317 Biomuta DOID:363 / uterine cancer [ cosmic ]
R1317 C1317 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R1359 K1359 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1566 N1566 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1583 Y1583 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1862 A1862 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1874 C1874 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1874 P1874 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1876 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1876 L1876 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2237 F2237 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2352 I2352 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2395 Y2395 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S2501 F2501 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2532 M2532 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2535 T2535 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2535 N2535 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
S2559 F2559 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y2601 C2601 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S2619 * Biomuta DOID:4159 / skin cancer [ cosmic ]