iPTMnet Report for Q9P2D0 (IBTK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P2D0 / IBTK_HUMAN
Protein Name Inhibitor of Bruton tyrosine kinase
Gene Name Name: IBTK
Synonyms:BTKI,KIAA1417;
Organism Homo sapiens (Human)

PRO ID PR:Q9P2D0
DAG View
PRO Name inhibitor of Bruton tyrosine kinase (human)
Definition An inhibitor of Bruton tyrosine kinase that is encoded in the genome of human.
Short Label hIBTK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P2D0 (IBTK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
Y630 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
K687 Methylation PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
C768 Methylation IEDB 31844290
C863 Methylation IEDB 31844290
S949 Phosphorylation PhosphoSitePlus
Y950 Phosphorylation PhosphoSitePlus
K981 Acetylation PhosphoSitePlus
K984 Acetylation PhosphoSitePlus
S990 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S992 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S993 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y996 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S999 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1006 Phosphorylation PhosphoSitePlus
T1008 Phosphorylation PhosphoSitePlus
T1016 Phosphorylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1033 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1039 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1045 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
T1049 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1054 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y1064 Phosphorylation PhosphoSitePlus
T1068 Phosphorylation PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus
Y1072 Phosphorylation PhosphoSitePlus
S1073 Phosphorylation PhosphoSitePlus
K1078 Ubiquitination PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
S1083 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1087 Ubiquitination PhosphoSitePlus
S1096 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1116 Phosphorylation PhosphoSitePlus   UniProt 20068231
T1138 Phosphorylation PhosphoSitePlus
K1140 Methylation PhosphoSitePlus
S1141 Phosphorylation PhosphoSitePlus
K1145 Methylation PhosphoSitePlus
K1145 Ubiquitination PhosphoSitePlus
K1152 Ubiquitination PhosphoSitePlus
T1181 Phosphorylation PhosphoSitePlus
S1198 Phosphorylation PhosphoSitePlus
S1200 Phosphorylation PhosphoSitePlus   Signor 21482705
S1200 Phosphorylation P05771 (PRKCB) PhosphoSitePlus   Signor 21482705
K1202 Ubiquitination PhosphoSitePlus
S1203 Phosphorylation PhosphoSitePlus   Signor 21482705
S1203 Phosphorylation P05771 (PRKCB) PhosphoSitePlus   Signor 21482705
K1212 Ubiquitination PhosphoSitePlus
K1230 Methylation PhosphoSitePlus
K1239 Ubiquitination PhosphoSitePlus
K1350 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S990 Phosphorylation HPRD 18669648
S992 Phosphorylation HPRD 18669648, 18452278
S993 Phosphorylation HPRD 18669648
Y996 Phosphorylation HPRD 18669648, 18452278
S1004 Phosphorylation HPRD 18669648
S1045 Phosphorylation HPRD 19651622, 18669648, 18452278, ...20068231, 18707149
T1049 Phosphorylation HPRD 18669648, 20068231
S1054 Phosphorylation HPRD 18669648
T1068 Phosphorylation HPRD 20068231
S1113 Phosphorylation HPRD 20068231
S1116 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K137 R137 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K475 N475 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K680 N680 Biomuta DOID:1319 / brain cancer [ cosmic ]
K745 T745 Biomuta DOID:363 / uterine cancer [ icgc ]
K751 N751 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S949 G949 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y950 H950 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y950 C950 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1039 N1039 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1045 F1045 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T1049 S1049 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1068 A1068 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1069 F1069 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1082 R1082 Biomuta DOID:363 / uterine cancer [ icgc ]
K1140 M1140 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1181 I1181 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1202 T1202 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K1350 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]