Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P286 / PAK5_HUMAN
Protein Name Serine/threonine-protein kinase PAK 5
Gene Name Name: PAK5
Synonyms:KIAA1264,PAK7;
Organism Homo sapiens (Human)

PRO ID PR:Q9P286
DAG View
PRO Name serine/threonine-protein kinase PAK 5 (human)
Definition A serine/threonine-protein kinase PAK 5 that is encoded in the genome of human.
Short Label hPAK5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P286 (PAK5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y159 Phosphorylation PhosphoSitePlus
K167 Acetylation PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
R285 Methylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
Y350 Phosphorylation PhosphoSitePlus
S573 Phosphorylation Q9P286 (PAK5) HPRD   phospho.ELM   PhosphoSitePlus 11756552
S602 Phosphorylation PhosphoSitePlus   RLIMS-P 17292838
T606 Phosphorylation PhosphoSitePlus


Q9P286 (PAK5) as PTM Enzyme



Substrate Site Score Source PMID
P15923 (TCF3) S39 PhosphoSitePlus 26212009
P15976 (GATA1) S161 PhosphoSitePlus 25726523
P15976 (GATA1) S187 PhosphoSitePlus 25726523
Q9P286 (PAK5) S573 phospho.ELM   PhosphoSitePlus 11756552


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K167 N167 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K167 E167 Biomuta DOID:363 / uterine cancer [ tcga ]
S183 C183 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
Y272 F272 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
T281 S281 Biomuta DOID:3571 / liver cancer [ tcga ]
R285 M285 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S290 W290 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S290 L290 Biomuta DOID:10534 / stomach cancer [ tcga ]