iPTMnet Report for Q9P212 (PLCE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P212 / PLCE1_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Gene Name Name: PLCE1
Synonyms:KIAA1516,PLCE,PPLC;
Organism Homo sapiens (Human)

PRO ID PR:Q9P212
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 that is encoded in the genome of human.
Short Label hPLCE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P212 (PLCE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S65 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
K576 Acetylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
T783 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
T994 Phosphorylation PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
T1006 Phosphorylation PhosphoSitePlus
S1096 Phosphorylation PhosphoSitePlus
T1100 Phosphorylation PhosphoSitePlus
T1259 Phosphorylation PhosphoSitePlus
Y1400 Phosphorylation PhosphoSitePlus
Y1401 Phosphorylation PhosphoSitePlus
Y1402 Phosphorylation PhosphoSitePlus
K1541 Methylation PhosphoSitePlus
K1555 Methylation PhosphoSitePlus
S1595 Phosphorylation PhosphoSitePlus
S1597 Phosphorylation PhosphoSitePlus
S1709 Phosphorylation PhosphoSitePlus
T1713 Phosphorylation PhosphoSitePlus
S1715 Phosphorylation PhosphoSitePlus
S1720 Phosphorylation PhosphoSitePlus
S2000 Phosphorylation PhosphoSitePlus
T2005 Phosphorylation PhosphoSitePlus
S2159 O-Glycosylation GlyGen 28657654
Site PTM Type PTM Enzyme Score Source PMID
S490 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S362 N362 Biomuta DOID:1319 / brain cancer [ icgc ]
T486 I486 Biomuta DOID:3571 / liver cancer [ cosmic ]
T486 S486 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S490 Y490 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S761 L761 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S761 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T1259 A1259 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1401 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]