iPTMnet Report for Q9P1Y6 (PHRF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P1Y6 / PHRF1_HUMAN
Protein Name PHD and RING finger domain-containing protein 1
Gene Name Name: PHRF1
Synonyms:KIAA1542;
Organism Homo sapiens (Human)

PRO ID PR:Q9P1Y6
DAG View
PRO Name PHD and RING finger domain-containing protein 1 (human)
Definition A PHD and RING finger domain-containing protein 1 that is encoded in the genome of human.
Short Label hPHRF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P1Y6 (PHRF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus   UniProt 23186163
S71 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
S98 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S101 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus   UniProt 19690332
T333 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
T396 Phosphorylation IEDB 35494241
S445 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus   UniProt 20068231
S458 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
K556 Methylation PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus
T591 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
T639 Phosphorylation PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
T674 Phosphorylation IEDB 35494241
R725 Methylation PhosphoSitePlus
T727 Phosphorylation PhosphoSitePlus
R749 Methylation PhosphoSitePlus
K768 Sumoylation PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S818 Phosphorylation PhosphoSitePlus
Y830 Phosphorylation PhosphoSitePlus
T836 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus   UniProt 24275569
S846 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935
S850 Phosphorylation PhosphoSitePlus
T860 O-Glycosylation GlyGen 23301498, 30379171, 28657654
S864 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S867 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
K869 Ubiquitination PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 24275569
T917 Phosphorylation PhosphoSitePlus   UniProt 19690332
T923 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S948 Phosphorylation PhosphoSitePlus
S950 Phosphorylation PhosphoSitePlus
T951 Phosphorylation PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
S973 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569, ...18220336
T981 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S991 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S993 Phosphorylation PhosphoSitePlus
S1032 Phosphorylation PhosphoSitePlus
S1034 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1095 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1124 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
T1126 Phosphorylation PhosphoSitePlus
S1127 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1128 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1142 Phosphorylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus
S1163 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
S1168 Phosphorylation PhosphoSitePlus
S1180 Phosphorylation PhosphoSitePlus
R1188 Methylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus
S1202 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 24275569
S1229 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S1324 Phosphorylation PhosphoSitePlus
S1359 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1360 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 24275569, 19690332
S1371 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S1389 Phosphorylation PhosphoSitePlus
T1391 Phosphorylation PhosphoSitePlus
T1404 Phosphorylation PhosphoSitePlus   UniProt 19690332
K1563 Acetylation PhosphoSitePlus
K1575 Ubiquitination PhosphoSitePlus
K1579 Ubiquitination PhosphoSitePlus
T1588 Phosphorylation PhosphoSitePlus
K1589 Acetylation PhosphoSitePlus
K1593 Acetylation PhosphoSitePlus
K1593 Ubiquitination PhosphoSitePlus
K1607 Ubiquitination PhosphoSitePlus
K1615 Ubiquitination PhosphoSitePlus
K1626 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 18452278
S73 Phosphorylation HPRD 18452278
S76 Phosphorylation HPRD 18452278
S98 Phosphorylation HPRD 18669648, 20068231
S544 Phosphorylation HPRD 20068231
S548 Phosphorylation HPRD 20068231
S844 Phosphorylation HPRD 19651622
S845 Phosphorylation HPRD 19651622, 15302935, 18452278
S863 Phosphorylation HPRD 18669648
S866 Phosphorylation HPRD 18669648
S914 Phosphorylation HPRD 17525332, 20230923
T916 Phosphorylation HPRD 17525332, 18077418, 20230923
S924 Phosphorylation HPRD 17525332, 18077418
S949 Phosphorylation HPRD 17081983
T950 Phosphorylation HPRD 17081983
S972 Phosphorylation HPRD 18669648, 20068231
T980 Phosphorylation HPRD 18669648
S990 Phosphorylation HPRD 17081983, 20068231
S1031 Phosphorylation HPRD 18452278
S1092 Phosphorylation HPRD 17081983
S1094 Phosphorylation HPRD 17081983
S1123 Phosphorylation HPRD 18669648, 17081983, 19664995
S1126 Phosphorylation HPRD 18669648
S1127 Phosphorylation HPRD 18669648
S1201 Phosphorylation HPRD 19651622, 15302935, 18669648, ...19664994, 20068231
S1228 Phosphorylation HPRD 19651622
S1358 Phosphorylation HPRD 19413330, 20058876, 17081983, ...19664995
S1359 Phosphorylation HPRD 19413330, 20058876, 18767875, ...15302935, 19664995, 20068231
S1370 Phosphorylation HPRD 19413330, 19651622
S1388 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S73 F73 Biomuta DOID:4159 / skin cancer [ cosmic ]
S98 F98 Biomuta DOID:4159 / skin cancer [ cosmic ]
S101 C101 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S101 Y101 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K168 N168 Biomuta DOID:4159 / skin cancer [ cosmic ]
S192 G192 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S306 T306 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T353 A353 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S358 C358 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T396 M396 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S480 F480 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T639 N639 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R749 W749 Biomuta DOID:4159 / skin cancer [ cosmic ]
S814 L814 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T836 I836 Biomuta DOID:4159 / skin cancer [ cosmic ]
S838 F838 Biomuta DOID:4159 / skin cancer [ cosmic ]
S850 F850 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S914 C914 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S915 C915 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S924 R924 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S925 R925 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S936 P936 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S948 F948 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T950 I950 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
T951 I951 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1094 R1094 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1095 R1095 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1126 R1126 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S1127 R1127 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
R1188 Q1188 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R1188 P1188 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1191 F1191 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1358 N1358 Biomuta DOID:363 / uterine cancer [ icgc ]
S1359 N1359 Biomuta DOID:363 / uterine cancer [ icgc ]
S1388 L1388 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S1389 L1389 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
T1588 I1588 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1607 R1607 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1607 N1607 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1626 E1626 Biomuta DOID:3571 / liver cancer [ cosmic ]