iPTMnet Report for Q9P0U4 (CXXC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P0U4 / CXXC1_HUMAN
Protein Name CXXC-type zinc finger protein 1
Gene Name Name: CXXC1
Synonyms:CFP1,CGBP,PCCX1,PHF18;
Organism Homo sapiens (Human)

PRO ID PR:Q9P0U4
DAG View
PRO Name CXXC-type zinc finger protein 1 (human)
Definition A CXXC-type zinc finger protein 1 that is encoded in the genome of human.
Short Label hCXXC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P0U4 (CXXC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 21406692
S6 Phosphorylation PhosphoSitePlus   UniProt 21406692
S17 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus   UniProt 21406692
K63 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus   UniProt 23186163
T126 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
K163 Methylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S224 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T227 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K250 Acetylation PhosphoSitePlus
K250 Sumoylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
K328 Methylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
R403 Methylation PhosphoSitePlus
Y405 Phosphorylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
Y509 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 19651622
S19 Phosphorylation HPRD 19651622
S224 Phosphorylation HPRD 18669648
T227 Phosphorylation HPRD 18669648
T513 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K63 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K63 N63 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S124 L124 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S143 F143 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S222 L222 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T227 M227 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S308 R308 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
R403 C403 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
R403 H403 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R403 S403 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K508 M508 Biomuta DOID:1324 / lung cancer [ cosmic ]
T521 I521 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K557 T557 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K611 R611 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]