iPTMnet Report for Q9P0U3 (SENP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P0U3 / SENP1_HUMAN
Protein Name Sentrin-specific protease 1
Gene Name Name: SENP1
Organism Homo sapiens (Human)

PRO ID PR:Q9P0U3
DAG View
PRO Name sentrin-specific protease 1 (human)
Definition A sentrin-specific protease 1 that is encoded in the genome of human.
Short Label hSENP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P0U3 (SENP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation PhosphoSitePlus   UniProt 23186163
T59 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus   UniProt 23186163
K124 Methylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K136 Methylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S157 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S159 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus   RLIMS-P 35186948
T328 Phosphorylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
K364 Acetylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
K396 Acetylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
T414 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K429 Acetylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
C560 Methylation IEDB 31844290
K577 Ubiquitination PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S57 F57 Biomuta DOID:4159 / skin cancer [ cosmic ]
T59 A59 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T59 I59 Biomuta DOID:1324 / lung cancer [ cosmic ]
S78 L78 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S80 R80 Biomuta DOID:10534 / stomach cancer [ icgc ]
S80 G80 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S127 N127 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S130 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S149 Y149 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S180 N180 Biomuta DOID:4159 / skin cancer [ cosmic ]
T328 I328 Biomuta DOID:4159 / skin cancer [ cosmic ]
K364 T364 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K432 N432 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K609 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]