iPTMnet Report for Q9P0M6 (MACROH2A2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P0M6 / H2AW_HUMAN
Protein Name Core histone macro-H2A.2
Gene Name Name: MACROH2A2
Synonyms:H2AFY2;
Organism Homo sapiens (Human)

PRO ID PR:Q9P0M6
DAG View
PRO Name core histone macro-H2A.2 (human)
Definition A core histone macro-H2A.2 that is encoded in the genome of human.
Short Label hMACROH2A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P0M6 (MACROH2A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 O-Glycosylation GlyGen 30379171, 34019948
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
R27 Methylation PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S129 Phosphorylation HPRD   PhosphoSitePlus 19413330
S160 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
K304 Acetylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K12 R12 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S165 G165 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S198 F198 Biomuta DOID:363 / uterine cancer [ icgc ]
K239 N239 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K304 N304 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]