iPTMnet Report for Q9P0L2 (MARK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P0L2 / MARK1_HUMAN
Protein Name Serine/threonine-protein kinase MARK1
Gene Name Name: MARK1
Synonyms:KIAA1477;
Organism Homo sapiens (Human)

PRO ID PR:Q9P0L2
DAG View
PRO Name serine/threonine-protein kinase MARK1 (human)
Definition A serine/threonine-protein kinase MARK1 that is encoded in the genome of human.
Short Label hMARK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P0L2 (MARK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus   UniProt 18691976
S36 Phosphorylation PhosphoSitePlus
R37 Methylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
T65 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
T208 Phosphorylation RLIMS-P   UniProt 17573348, 14517247
T215 Phosphorylation Q15831 (STK11) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 17573348, 14976552
S219 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus   UniProt 18691976
S414 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
Y494 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
Y505 Phosphorylation PhosphoSitePlus
Y514 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus
S588 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S590 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S593 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
T596 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T598 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S612 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T613 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
R646 Methylation PhosphoSitePlus
T648 Phosphorylation PhosphoSitePlus
S649 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
S666 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation HPRD 18691976
S46 Phosphorylation HPRD 18691976
T215 Phosphorylation Q15831 (STK11) , Q7L7X3 (TAOK1) HPRD 18691976, 14517247, 14976552
S219 Phosphorylation Q15831 (STK11) HPRD 18691976, 14976552
S393 Phosphorylation HPRD 18691976
S399 Phosphorylation HPRD 18691976
T400 Phosphorylation HPRD 18691976
S403 Phosphorylation HPRD 18691976
S423 Phosphorylation HPRD 18691976
S475 Phosphorylation HPRD 18691976
S588 Phosphorylation HPRD 18691976, 18669648
T596 Phosphorylation HPRD 18669648
S633 Phosphorylation HPRD 18691976
T648 Phosphorylation HPRD 18691976


Q9P0L2 (MARK1) as PTM Enzyme



Substrate Site Score Source PMID
P10636-2 (MAPT) S204 HPRD 8999860, 9771888, 10090741, ...12387894, 9832145, 7706316, 9735171
P10636-8 (MAPT) T212 neXtProt 21985311
P10636-8 (MAPT) S214 neXtProt 21985311
P10636-8 (MAPT) T217 neXtProt 21985311
P10636-8 (MAPT) T231 PhosphoSitePlus 21204788
P10636-2 (MAPT) S235 HPRD 7931292, 7706316
P10636-6 (MAPT) S247 HPRD 7706316
P10636-8 (MAPT) S262 HPRD   PhosphoSitePlus 18424437, 8999860, 9771888, ...10090741, 9614189, 12387894, 9832145, 7706316, 21204788, 9735171
P10636-6 (MAPT) S266 HPRD 7931292, 7706316
P10636-2 (MAPT) S267 HPRD 9771888, 10737616, 12387894, ...9832145, 7706316, 12435421
P10636-8 (MAPT) S293 HPRD   PhosphoSitePlus 7706316, 9614189
P10636-6 (MAPT) S298 HPRD 9771888, 10737616, 12387894, ...9832145, 7706316, 12435421
P10636-8 (MAPT) S305 HPRD   PhosphoSitePlus 7706316
P10636-8 (MAPT) S320 PhosphoSitePlus 10090741
P10636-8 (MAPT) S324 HPRD   PhosphoSitePlus 10090741, 7931292, 7706316, ...9614189
P10636-8 (MAPT) S356 HPRD   PhosphoSitePlus 9771888, 10090741, 12387894, ...10737616, 9614189, 21204788, 9832145, 7706316, 12435421
P10636-8 (MAPT) S396 neXtProt   PhosphoSitePlus 21985311, 21204788
P10636-8 (MAPT) S422 PhosphoSitePlus 21204788
P10636 (MAPT) S579 Signor 21215781
P10636 (MAPT) S641 Signor 21215781
P10636 (MAPT) S673 Signor 21215781
P11137-2 (MAP2) S184 HPRD 8631898
P11137-2 (MAP2) S323 HPRD 8631898
P11137-2 (MAP2) S354 HPRD 8631898
P11137 (MAP2) S385 HPRD 8631898
P11137-2 (MAP2) S439 HPRD 8631898
P11137-2 (MAP2) S443 HPRD 8631898
P11137-2 (MAP2) S446 HPRD 8631898
P11137-1 (MAP2) S1540 HPRD 8631898
P11137-1 (MAP2) S1679 HPRD   neXtProt 8631898
P11137-1 (MAP2) S1710 HPRD   neXtProt 8631898
P11137-1 (MAP2) S1795 HPRD 8631898
P11137-1 (MAP2) S1799 HPRD 8631898
P11137-1 (MAP2) S1802 HPRD 8631898
P27816-1 (MAP4) S928 HPRD 20166139, 18767875, 20058876, ...20068231, 8631898
P27816-1 (MAP4) S941 HPRD   neXtProt 20166139, 18669648, 20068231, ...8631898
P27816-1 (MAP4) S1073 HPRD   neXtProt 18212344, 18707149, 18452278, ...19651622, 18669648, 20068231, 17693683, 20166139, 19415658, 8631898


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T5 M5 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S36 N36 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S36 G36 Biomuta DOID:3571 / liver cancer [ cosmic ]
T65 A65 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K68 Q68 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S219 N219 Biomuta DOID:1324 / lung cancer [ cosmic ]
K231 N231 Biomuta DOID:1324 / lung cancer [ cosmic ]
K307 E307 Biomuta DOID:363 / uterine cancer [ icgc ]
S382 Y382 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S399 N399 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S399 C399 Biomuta DOID:4159 / skin cancer [ cosmic ]
S470 R470 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S475 I475 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y505 H505 Biomuta DOID:4159 / skin cancer [ cosmic ]
S524 N524 Biomuta DOID:4159 / skin cancer [ cosmic ]
S524 I524 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T580 I580 Biomuta DOID:184 / bone cancer [ cosmic ]
T581 A581 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S588 F588 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S590 F590 Biomuta DOID:4159 / skin cancer [ cosmic ]
S593 G593 Biomuta DOID:3571 / liver cancer [ cosmic ]
S624 I624 Biomuta DOID:3571 / liver cancer [ cosmic ]
T648 M648 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T648 A648 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S679 T679 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S699 C699 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S699 Y699 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T709 I709 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S710 G710 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]