iPTMnet Report for Q9P0J7 (KCMF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P0J7 / KCMF1_HUMAN
Protein Name E3 ubiquitin-protein ligase KCMF1
Gene Name Name: KCMF1
Synonyms:FIGC,ZZZ1;
Organism Homo sapiens (Human)

PRO ID PR:Q9P0J7
DAG View
PRO Name E3 ubiquitin-protein ligase KCMF1 (human)
Definition An E3 ubiquitin-protein ligase KCMF1 that is encoded in the genome of human.
Short Label hKCMF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P0J7 (KCMF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 20068231
S2 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231
R3 Methylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
R149 Methylation PhosphoSitePlus
R159 Methylation PhosphoSitePlus
R165 Methylation PhosphoSitePlus
R167 Methylation PhosphoSitePlus
R168 Methylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus   UniProt 23186163
S175 O-Glycosylation GlyGen 34019948, 28510447, 29237092
S177 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation HPRD   PhosphoSitePlus 18691976
Y188 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   UniProt 23186163
S204 Phosphorylation PhosphoSitePlus
S207 Phosphorylation HPRD   PhosphoSitePlus 20068231
S212 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
S223 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus   UniProt 24275569
S336 Phosphorylation PhosphoSitePlus   UniProt 24275569


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K14 N14 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S145 L145 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R149 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R149 Q149 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R159 L159 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R159 W159 Biomuta DOID:4159 / skin cancer [ cosmic ]
R165 G165 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R167 H167 Biomuta DOID:4159 / skin cancer [ cosmic ]
R168 K168 Biomuta DOID:4159 / skin cancer [ cosmic ]
S169 L169 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S189 Y189 Biomuta DOID:363 / uterine cancer [ icgc ]
S334 * Biomuta DOID:1324 / lung cancer [ cosmic ]