Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P0J1 / PDP1_HUMAN
Protein Name [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial precursor
Gene Name Name: PDP1
Synonyms:PDP,PPM2C;
Organism Homo sapiens (Human)

PRO ID PR:Q9P0J1
DAG View
PRO Name [pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (human)
Definition A [pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial that is encoded in the genome of human.
Short Label hPDP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P0J1 (PDP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R43 Methylation PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
Y79 Phosphorylation PhosphoSitePlus
S87 O-Glycosylation GlyGen 29351928
K90 Ubiquitination PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus   RLIMS-P 32782783, 24962578
K97 Ubiquitination PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
T172 Phosphorylation RLIMS-P 28595656
K194 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
K202 Acetylation PhosphoSitePlus   UniProt 19608861
K202 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K241 Acetylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K357 Acetylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K366 Sumoylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
Y381 Phosphorylation P11362 (FGFR1) , P00533 (EGFR) PhosphoSitePlus   RLIMS-P 24486017, 24962578
K383 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K468 Acetylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K502 Acetylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R43 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K206 I206 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
K339 E339 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K366 N366 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K411 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]