iPTMnet Report for Q9P035 (HACD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9P035 / HACD3_HUMAN
Protein Name Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
Gene Name Name: HACD3
Synonyms:BIND1;
Organism Homo sapiens (Human)

PRO ID PR:Q9P035
DAG View
PRO Name very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (human)
Definition A very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 that is encoded in the genome of human.
Short Label hHACD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9P035 (HACD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 25944712
T7 Phosphorylation PhosphoSitePlus   UniProt 23186163
R15 Methylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
R92 Methylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
R99 Methylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18220336, 18318008, 18691976, 24275569, 19690332, 20068231
K130 Ubiquitination PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus   UniProt 23186163
S138 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S114 Phosphorylation HPRD 19413330, 18691976, 18578522, ...19562805, 18767875, 19664994, 20058876, 19691289, 19664995, 19651622, 15302935, 18669648, 20166139, 18452278, 15345747, 19415658, 20068231, 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S114 C114 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S138 F138 Biomuta DOID:4159 / skin cancer [ cosmic ]