iPTMnet Report for Q9NZT2 (OGFR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZT2 / OGFR_HUMAN
Protein Name Opioid growth factor receptor
Gene Name Name: OGFR
Organism Homo sapiens (Human)

PRO ID PR:Q9NZT2
DAG View
PRO Name opioid growth factor receptor (human)
Definition An opioid growth factor receptor that is encoded in the genome of human.
Short Label hOGFR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZT2 (OGFR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S45 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus   UniProt 23186163
K309 Sumoylation PhosphoSitePlus
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569, 17287340, 20068231
S324 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
S349 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S361 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S378 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...18234856, 18318008, 18669648, 24275569, 19690332, 20068231
S382 Phosphorylation PhosphoSitePlus   UniProt 23186163
S390 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus   UniProt 23186163
S420 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
S423 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
T478 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S484 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S488 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus   UniProt 20068231
S557 Phosphorylation PhosphoSitePlus   UniProt 20068231
S577 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T581 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus   UniProt 20068231
S637 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T641 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
T650 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S315 Phosphorylation HPRD 19413330, 18491316, 17287340, ...17081983, 19651622, 18510355, 18707149, 20166139, 19415658, 20068231, 18212344
S349 Phosphorylation HPRD 18669648, 20058876, 18212344, ...20068231
S361 Phosphorylation HPRD 18669648, 20068231
S378 Phosphorylation HPRD 18491316, 17081983, 18767875, ...19651622, 18510355, 18669648, 18707149, 20166139, 20068231
S420 Phosphorylation HPRD 17525332, 18077418, 20068231
T428 Phosphorylation HPRD 18077418
T478 Phosphorylation HPRD 18669648, 20068231
S484 Phosphorylation HPRD 18669648, 20068231
S517 Phosphorylation HPRD 19664994, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S45 W45 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K158 R158 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S378 I378 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S403 C403 Biomuta DOID:1324 / lung cancer [ cosmic ]
T426 M426 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S496 N496 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S525 R525 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S537 T537 Biomuta DOID:3571 / liver cancer [ cosmic ]
S557 T557 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S577 T577 Biomuta DOID:1781 / thyroid cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T581 P581 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S585 R585 Biomuta DOID:263 / kidney cancer [ cosmic ]
S637 T637 Biomuta [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
T641 A641 Biomuta DOID:363 / uterine cancer [ icgc ]
S645 R645 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T650 A650 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]