iPTMnet Report for Q9NZQ7 (CD274)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZQ7 / PD1L1_HUMAN
Protein Name Programmed cell death 1 ligand 1 precursor
Gene Name Name: CD274
Synonyms:B7H1,PDCD1L1,PDCD1LG1,PDL1;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZQ7
DAG View
PRO Name programmed cell death 1 ligand 1 (human)
Definition A programmed cell death 1 ligand 1 that is encoded in the genome of human.
Short Label hCD274
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZQ7 (CD274) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation RLIMS-P 33324209
Y112 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
T180 Phosphorylation PhosphoSitePlus   RLIMS-P 33879767
S184 Phosphorylation PhosphoSitePlus   RLIMS-P 33879767
N192 N-Glycosylation GlyGen   UniProt 19159218, 24190977
T194 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus   RLIMS-P 30118680
N200 N-Glycosylation GlyGen 24190977
N204 N-Glycosylation GlyGen 24190977
T210 Phosphorylation PhosphoSitePlus
N219 N-Glycosylation GlyGen 24190977
K263 Acetylation PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus   RLIMS-P 33879767
K281 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus   RLIMS-P 33879767
T285 Phosphorylation PhosphoSitePlus   RLIMS-P 35385574
T290 Phosphorylation PhosphoSitePlus   RLIMS-P 35385574


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NZQ7 (CD274) S279 Q9Z1K5 (Arih1) increased_association eFIP 33879767


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T210 S210 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T285 A285 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T290 M290 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]