iPTMnet Report for Q9NZN8 (CNOT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZN8 / CNOT2_HUMAN
Protein Name CCR4-NOT transcription complex subunit 2
Gene Name Name: CNOT2
Synonyms:CDC36,NOT2;ORFNames:HSPC131,MSTP046;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZN8
DAG View
PRO Name CCR4-NOT transcription complex subunit 2 (human)
Definition A CCR4-NOT transcription complex subunit 2 that is encoded in the genome of human.
Short Label hCNOT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZN8 (CNOT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation IEDB 27920218
K12 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S63 Phosphorylation phospho.ELM 18669648
S65 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
R87 Methylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
T93 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S99 Phosphorylation PhosphoSitePlus
S101 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
S101 Phosphorylation phospho.ELM   PhosphoSitePlus 18077418, 17525332, 18669648
S101 Phosphorylation Q13535 (ATR) PhosphoSitePlus 18077418
T104 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
T111 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
T111 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T113 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
T113 Phosphorylation PhosphoSitePlus
T114 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
T114 Phosphorylation PhosphoSitePlus
T118 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
T118 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S120 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
S120 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T123 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S126 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
S126 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S128 Phosphorylation PhosphoSitePlus
R137 Methylation PhosphoSitePlus
S143 O-Glycosylation GlyGen 30059200
S143 Phosphorylation PhosphoSitePlus
T155 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
T155 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S160 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S161 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S165 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18669648, 24275569, 20068231
S169 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 34019948, 30379171, 32574038, 30059200, 35254053, 35132862, 32119511, 35289036, 29351928, 36240223
S169 Phosphorylation PhosphoSitePlus
S170 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S242 Phosphorylation PhosphoSitePlus   UniProt 23186163
T246 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus   UniProt 24275569
S293 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
K299 Acetylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
Y471 Phosphorylation PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
Y494 Phosphorylation PhosphoSitePlus
Y500 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S63 Phosphorylation HPRD 18669648
T64 Phosphorylation HPRD 20068231
T93 Phosphorylation HPRD 18669648
S101 Phosphorylation HPRD 18077418, 17525332, 18669648, ...20068231
T111 Phosphorylation HPRD 18669648, 20068231
T118 Phosphorylation HPRD 18691976, 18669648
S120 Phosphorylation HPRD 18669648
T123 Phosphorylation HPRD 18669648
S126 Phosphorylation HPRD 18691976, 18669648
S128 Phosphorylation HPRD 20068231
T155 Phosphorylation HPRD 20068231
S160 Phosphorylation HPRD 18669648
S161 Phosphorylation HPRD 18691976, 18669648, 20068231
S165 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19664995, 19651622, 17322306, 18669648, 18707149, 19415658, 20068231
S169 Phosphorylation HPRD 20068231
S170 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S45 N45 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S47 F47 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S47 P47 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S65 L65 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T93 A93 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S101 L101 Biomuta DOID:363 / uterine cancer [ icgc ]
T123 M123 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ]
R137 G137 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R137 W137 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S170 L170 Biomuta DOID:363 / uterine cancer [ icgc ]
S391 F391 Biomuta DOID:4159 / skin cancer [ cosmic ]
S391 C391 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y500 H500 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]