iPTMnet Report for Q9NZN5 (ARHGEF12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZN5 / ARHGC_HUMAN
Protein Name Rho guanine nucleotide exchange factor 12
Gene Name Name: ARHGEF12
Synonyms:KIAA0382,LARG;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZN5
DAG View
PRO Name Rho guanine nucleotide exchange factor 12 (human)
Definition A Rho guanine nucleotide exchange factor 12 that is encoded in the genome of human.
Short Label hARHGEF12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZN5 (ARHGEF12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
R11 Methylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
S41 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569, ...18220336
Y66 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus   RLIMS-P 26483157, 29279389
K205 Ubiquitination PhosphoSitePlus
T230 Phosphorylation IEDB 35494241
C294 S-Nitrosylation dbSNO 26338901
S296 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S312 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S341 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T532 Phosphorylation PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
K591 Acetylation PhosphoSitePlus
K593 Acetylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
R617 Methylation PhosphoSitePlus
T632 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
Y660 Phosphorylation PhosphoSitePlus
T693 Phosphorylation PhosphoSitePlus
T699 Phosphorylation PhosphoSitePlus
T703 Phosphorylation PhosphoSitePlus
T732 Phosphorylation PhosphoSitePlus
T736 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18088087
S753 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
S824 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
R829 Methylation PhosphoSitePlus
C921 S-Nitrosylation dbSNO 26338901
K1000 Ubiquitination PhosphoSitePlus
Y1004 Phosphorylation PhosphoSitePlus
K1017 Ubiquitination PhosphoSitePlus
K1064 Ubiquitination PhosphoSitePlus
S1072 Phosphorylation PhosphoSitePlus
S1170 Phosphorylation PhosphoSitePlus
S1176 Phosphorylation PhosphoSitePlus   RLIMS-P 26483157, 29279389
S1203 Phosphorylation PhosphoSitePlus
Y1232 Phosphorylation PhosphoSitePlus
S1239 Phosphorylation PhosphoSitePlus
S1273 Phosphorylation PhosphoSitePlus
Y1284 Phosphorylation PhosphoSitePlus
T1286 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1288 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 23186163, 18669648, ...29279389
T1293 Phosphorylation PhosphoSitePlus
S1295 Phosphorylation PhosphoSitePlus
S1308 Phosphorylation PhosphoSitePlus
T1324 Phosphorylation PhosphoSitePlus
Y1326 Phosphorylation PhosphoSitePlus
S1327 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1331 O-Glycosylation GlyGen 30379171, 28657654, 30620550
S1331 Phosphorylation PhosphoSitePlus
S1377 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1389 Phosphorylation PhosphoSitePlus
Y1415 Phosphorylation PhosphoSitePlus
S1457 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1463 Phosphorylation PhosphoSitePlus
S1468 Phosphorylation PhosphoSitePlus
T1471 Phosphorylation PhosphoSitePlus
S1492 Phosphorylation PhosphoSitePlus
Y1524 Phosphorylation PhosphoSitePlus
T1525 Phosphorylation PhosphoSitePlus
S1541 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1544 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 18212344
S190 Phosphorylation HPRD 20068231
S341 Phosphorylation HPRD 18669648, 15345747
Y546 Phosphorylation HPRD 18491316
S637 Phosphorylation HPRD 20068231
T736 Phosphorylation HPRD 18088087
T1286 Phosphorylation HPRD 19413330, 18669648
S1288 Phosphorylation HPRD 17525332, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
T1267 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 N2 Biomuta DOID:3571 / liver cancer [ cosmic ]
T9 S9 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R11 S11 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y546 C546 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y546 F546 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S599 N599 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T736 A736 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R829 Q829 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1004 H1004 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1017 N1017 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1170 L1170 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S1170 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
Y1232 N1232 Biomuta DOID:3565 / meningioma [ cosmic ]
Y1326 H1326 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1525 S1525 Biomuta DOID:4606 / bile duct cancer [ cosmic ]