iPTMnet Report for Q9NZM3 (ITSN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZM3 / ITSN2_HUMAN
Protein Name Intersectin-2
Gene Name Name: ITSN2
Synonyms:KIAA1256,SH3D1B,SWAP;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZM3
DAG View
PRO Name intersectin-2 (human)
Definition An intersectin-2 that is encoded in the genome of human.
Short Label hITSN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZM3 (ITSN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y39 Phosphorylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus   UniProt 23186163
S126 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
T138 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S139 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S183 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S184 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S185 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
T186 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S191 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S192 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
Y193 Phosphorylation PhosphoSitePlus
S210 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S210 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S216 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
T220 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S222 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S230 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 29351928, 34725712, 34019948, 30059200, 35132862, 31492838, 32119511, 30620550, 29237092
S230 Phosphorylation PhosphoSitePlus   UniProt 20068231
T233 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K424 Acetylation PhosphoSitePlus
K428 Acetylation PhosphoSitePlus
C530 Methylation IEDB 31844290
Y553 Phosphorylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K583 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
Y665 Phosphorylation PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
Y859 Phosphorylation PhosphoSitePlus
T882 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus   UniProt 23186163
S887 Phosphorylation PhosphoSitePlus
S889 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 20068231
S908 Phosphorylation PhosphoSitePlus
K913 Ubiquitination PhosphoSitePlus
T926 Phosphorylation IEDB 32387766
Y950 Phosphorylation PhosphoSitePlus
K952 Ubiquitination PhosphoSitePlus
S957 Phosphorylation PhosphoSitePlus
Y968 Phosphorylation PhosphoSitePlus   UniProt 15592455, 15144186, 19690332, ...20068231
S1041 Phosphorylation PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
T1123 Phosphorylation PhosphoSitePlus
T1277 Phosphorylation PhosphoSitePlus
T1579 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation HPRD 20068231
T24 Phosphorylation HPRD 20068231
S210 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 20068231
S230 Phosphorylation HPRD 20068231
Y553 Phosphorylation HPRD 15951569, 20068231, 16497976
T573 Phosphorylation HPRD 18767875, 20068231
S579 Phosphorylation HPRD 18767875
Y859 Phosphorylation HPRD 15592455
T882 Phosphorylation HPRD 18691976
S884 Phosphorylation HPRD 19413330, 18691976, 18669648, ...15144186, 20068231
S887 Phosphorylation HPRD 18669648
S889 Phosphorylation HPRD 19413330, 18767875, 15144186, ...18452278, 19651622, 18669648, 20068231
Y968 Phosphorylation HPRD 19901323, 17389395, 15144186, ...18707149, 20068231, 16497976
S1263 Phosphorylation HPRD 20068231
T1265 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation HPRD 20068231
T24 Phosphorylation HPRD 20068231
S210 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 20068231
S230 Phosphorylation HPRD 20068231
Y553 Phosphorylation HPRD 15951569, 20068231, 16497976
T573 Phosphorylation HPRD 18767875, 20068231
S579 Phosphorylation HPRD 18767875
K621 Ubiquitination PhosphoSitePlus
Y832 Phosphorylation HPRD 15592455
T855 Phosphorylation HPRD 18691976
S857 Phosphorylation HPRD 19413330, 18691976, 18669648, ...15144186, 20068231
S860 Phosphorylation HPRD 18669648
S862 Phosphorylation HPRD 19413330, 18767875, 15144186, ...18452278, 19651622, 18669648, 20068231
Y941 Phosphorylation HPRD 19901323, 17389395, 15144186, ...18707149, 20068231, 16497976
S1236 Phosphorylation HPRD 20068231
T1238 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation HPRD 20068231
T24 Phosphorylation HPRD 20068231
S210 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 20068231
S230 Phosphorylation HPRD 20068231
Y553 Phosphorylation HPRD 15951569, 20068231, 16497976
T573 Phosphorylation HPRD 18767875, 20068231
S579 Phosphorylation HPRD 18767875
Y859 Phosphorylation HPRD 15592455
T882 Phosphorylation HPRD 18691976
S884 Phosphorylation HPRD 19413330, 18691976, 18669648, ...15144186, 20068231
S887 Phosphorylation HPRD 18669648
S889 Phosphorylation HPRD 19413330, 18767875, 15144186, ...18452278, 19651622, 18669648, 20068231
Y968 Phosphorylation HPRD 19901323, 17389395, 15144186, ...18707149, 20068231, 16497976
S1249 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S184 F184 Biomuta DOID:4159 / skin cancer [ cosmic ]
S222 L222 Biomuta DOID:4159 / skin cancer [ cosmic ]
K358 N358 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K428 E428 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K428 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K584 T584 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K584 Q584 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S826 F826 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S860 F860 Biomuta DOID:4159 / skin cancer [ cosmic ]
S862 L862 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S887 F887 Biomuta DOID:4159 / skin cancer [ cosmic ]
S889 L889 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S908 F908 Biomuta DOID:1612 / breast cancer [ icgc ]
Y941 C941 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K952 N952 Biomuta DOID:1319 / brain cancer [ icgc ]
Y968 C968 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1051 L1051 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T1277 A1277 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1579 K1579 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T1579 I1579 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]