iPTMnet Report for Q9NZK5 (ADA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZK5 / ADA2_HUMAN
Protein Name Adenosine deaminase 2 precursor
Gene Name Name: ADA2
Synonyms:ADGF,CECR1,IDGFL;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZK5
DAG View
PRO Name adenosine deaminase 2 (human)
Definition An adenosine deaminase 2 that is encoded in the genome of human.
Short Label hADA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZK5 (ADA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
T65 O-Glycosylation GlyGen 30620550
K67 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
N127 N-Glycosylation GlyGen   UniProt 20147294, 29391424
K161 Ubiquitination PhosphoSitePlus
N174 N-Glycosylation GlyGen   UniProt 19159218, 29391424, 24190977
N185 N-Glycosylation GlyGen   UniProt 20147294, 29391424
K267 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
Y337 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
N378 N-Glycosylation GlyGen   UniProt 20147294, 19159218, 29391424, ...24190977
K390 Ubiquitination PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T65 M65 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K72 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
N185 H185 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K267 N267 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K275 N275 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K275 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S333 F333 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y337 F337 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K401 N401 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]