iPTMnet Report for Q9NZJ4 (SACS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZJ4 / SACS_HUMAN
Protein Name Sacsin
Gene Name Name: SACS
Synonyms:KIAA0730;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZJ4
DAG View
PRO Name sacsin (human)
Definition A sacsin that is encoded in the genome of human.
Short Label hSACS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZJ4 (SACS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K70 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
C205 Methylation IEDB 31844290
K238 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
T898 Phosphorylation PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
S909 Phosphorylation PhosphoSitePlus
S914 Phosphorylation PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
K943 Acetylation PhosphoSitePlus   UniProt 19608861
K955 Ubiquitination PhosphoSitePlus
K982 Ubiquitination PhosphoSitePlus
K987 Ubiquitination PhosphoSitePlus
T989 Phosphorylation PhosphoSitePlus
K1093 Ubiquitination PhosphoSitePlus
K1109 Ubiquitination PhosphoSitePlus
K1274 Ubiquitination PhosphoSitePlus
K1342 Ubiquitination PhosphoSitePlus
K1435 Methylation PhosphoSitePlus
K1435 Ubiquitination PhosphoSitePlus
K1465 Ubiquitination PhosphoSitePlus
C1663 Methylation IEDB 31844290
S1706 Phosphorylation PhosphoSitePlus
T1711 Phosphorylation PhosphoSitePlus
K1715 Ubiquitination PhosphoSitePlus
K1737 Acetylation PhosphoSitePlus
S1779 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 20068231
K1797 Ubiquitination PhosphoSitePlus
S1809 Phosphorylation PhosphoSitePlus
T1910 Phosphorylation PhosphoSitePlus
T1911 Phosphorylation PhosphoSitePlus
K1989 Ubiquitination PhosphoSitePlus
S1997 Phosphorylation PhosphoSitePlus
K2000 Ubiquitination PhosphoSitePlus
K2043 Ubiquitination PhosphoSitePlus
Y2139 Phosphorylation PhosphoSitePlus
C2182 Methylation IEDB 31844290
Y2210 Phosphorylation PhosphoSitePlus
C2255 Methylation IEDB 31844290
K2334 Acetylation PhosphoSitePlus
K2358 Acetylation PhosphoSitePlus
K2414 Ubiquitination PhosphoSitePlus
K2495 Acetylation PhosphoSitePlus
K2495 Ubiquitination PhosphoSitePlus
K2501 Acetylation PhosphoSitePlus
Y2509 Phosphorylation PhosphoSitePlus
S2511 Phosphorylation PhosphoSitePlus
K2709 Ubiquitination PhosphoSitePlus
T2858 O-Glycosylation GlyGen 30379171, 28411811, 35254053
K3049 Ubiquitination PhosphoSitePlus
T3124 Phosphorylation PhosphoSitePlus
Y3177 Phosphorylation PhosphoSitePlus
S3197 O-Glycosylation GlyGen 30379171, 28411811, 35254053
Y3367 Phosphorylation PhosphoSitePlus
S3435 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y3463 Phosphorylation PhosphoSitePlus
Y3477 Phosphorylation PhosphoSitePlus
K3501 Ubiquitination PhosphoSitePlus
K3514 Ubiquitination PhosphoSitePlus
K3894 Ubiquitination PhosphoSitePlus
K3918 Ubiquitination PhosphoSitePlus
K4033 Ubiquitination PhosphoSitePlus
Y4177 Phosphorylation PhosphoSitePlus
Y4181 Phosphorylation PhosphoSitePlus
S4251 Phosphorylation PhosphoSitePlus
S4257 Phosphorylation PhosphoSitePlus
S4260 Phosphorylation PhosphoSitePlus
T4261 Phosphorylation PhosphoSitePlus
T4263 Phosphorylation PhosphoSitePlus
S4264 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T4266 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T4270 Phosphorylation PhosphoSitePlus
S4302 Phosphorylation PhosphoSitePlus
Y4333 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K4364 Ubiquitination PhosphoSitePlus
R4374 Methylation PhosphoSitePlus
K4419 Ubiquitination PhosphoSitePlus
Y4428 Phosphorylation PhosphoSitePlus
K4439 Methylation PhosphoSitePlus
K4439 Ubiquitination PhosphoSitePlus
K4578 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S338 Phosphorylation HPRD 19413330
S1779 Phosphorylation HPRD 19664994, 20068231
S4264 Phosphorylation HPRD 18669648, 20068231
T4266 Phosphorylation HPRD 18669648
S4302 Phosphorylation HPRD 20068231
Y4333 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K238 E238 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K238 I238 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K289 N289 Biomuta DOID:363 / uterine cancer [ icgc ]
K514 Q514 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K854 Q854 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K865 T865 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S909 C909 Biomuta DOID:1324 / lung cancer [ cosmic ]
K987 N987 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1109 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1274 N1274 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1342 T1342 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1663 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S1809 L1809 Biomuta DOID:363 / uterine cancer [ icgc ]
T1911 M1911 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
K1989 N1989 Biomuta DOID:363 / uterine cancer [ icgc ]
S1997 C1997 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K2000 T2000 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2334 N2334 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2334 T2334 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K2414 E2414 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K2709 N2709 Biomuta DOID:3565 / meningioma [ cosmic ]
T3124 A3124 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3435 R3435 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y3477 F3477 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S4260 F4260 Biomuta DOID:1324 / lung cancer [ cosmic ]
T4270 S4270 Biomuta DOID:3571 / liver cancer [ cosmic ]
S4302 A4302 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S4302 Y4302 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R4374 K4374 Biomuta DOID:3571 / liver cancer [ cosmic ]