iPTMnet Report for Q9NZC7 (WWOX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZC7 / WWOX_HUMAN
Protein Name WW domain-containing oxidoreductase
Gene Name Name: WWOX
Synonyms:FOR,SDR41C1,WOX1;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZC7
DAG View
PRO Name WW domain-containing oxidoreductase (human)
Definition A WW domain-containing oxidoreductase that is encoded in the genome of human.
Short Label hWWOX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZC7 (WWOX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y6 Phosphorylation PhosphoSitePlus
T12 Phosphorylation PhosphoSitePlus   UniProt 19690332
S14 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29310447, 19690332, 30154439
K28 Ubiquitination PhosphoSitePlus
Y33 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15580310, 15070730, 18371080, ...24899407, 14555208, 19484134, 19366691, 24008736, 12514174, 16288044, 25649963, 17567906, 27339895, 26120275
Y33 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 15070730
K48 Ubiquitination PhosphoSitePlus
T49 Phosphorylation RLIMS-P 30154439
Y61 Phosphorylation phospho.ELM   RLIMS-P 22534828, 12514174
K100 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
Y287 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 20432460, 24899407, 16288044
Y287 Phosphorylation Q07912 (TNK2) neXtProt   PhosphoSitePlus 16288044
S312 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 15345747
Y33 Phosphorylation HPRD 15070730, 15580310, 12514174
Y33 Phosphorylation P12931 (SRC) HPRD 15070730
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 15345747
Y33 Phosphorylation HPRD 15070730, 15580310, 12514174
Y33 Phosphorylation P12931 (SRC) HPRD 15070730


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NZC7 (WWOX) Y33 P45983 (MAPK8) unknown eFIP 14555208
Phosphorylation Q9NZC7 (WWOX) Y33 O15350 (TP73) increased_association eFIP 24137446
Phosphorylation Q9NZC7 (WWOX) Y33 P04637 (TP53) unknown eFIP 23459853
Phosphorylation Q9NZC7 (WWOX) S14 P28482 (MAPK1) unknown eFIP 29581896


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q9NZC7-1 (hWWOX/iso:1) Interaction PR:000036589 (hEZR/iso:1/Phos:2) PRO 16438931


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T49 A49 Biomuta DOID:1324 / lung cancer [ cosmic ]
K100 R100 Biomuta DOID:363 / uterine cancer [ icgc ]