iPTMnet Report for Q9NZ08 (ERAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NZ08 / ERAP1_HUMAN
Protein Name Endoplasmic reticulum aminopeptidase 1
Gene Name Name: ERAP1
Synonyms:APPILS,ARTS1,KIAA0525;ORFNames:UNQ584/PRO1154;
Organism Homo sapiens (Human)

PRO ID PR:Q9NZ08
DAG View
PRO Name endoplasmic reticulum aminopeptidase 1 (human)
Definition An endoplasmic reticulum aminopeptidase 1 that is encoded in the genome of human.
Short Label hERAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NZ08 (ERAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N70 N-Glycosylation GlyGen   UniProt 21478864
N154 N-Glycosylation GlyGen   UniProt 21478864
S179 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
C193 Methylation IEDB 31844290
S268 Phosphorylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
N414 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
K440 Ubiquitination PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
T559 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation PhosphoSitePlus
C743 Methylation IEDB 31844290
N760 N-Glycosylation GlyGen   UniProt 21478864
K811 Acetylation PhosphoSitePlus
S903 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation HPRD 20068231
T185 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation HPRD 20068231
T185 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N154 T154 Biomuta DOID:363 / uterine cancer [ icgc ]
S179 L179 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
N414 H414 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K440 T440 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y464 H464 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]