Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9NYY3 / PLK2_HUMAN
Protein Name Serine/threonine-protein kinase PLK2
Gene Name Name: PLK2
Organism Homo sapiens (Human)

DAG View
PRO Name serine/threonine-protein kinase PLK2 (human)
Definition A serine/threonine-protein kinase PLK2 that is encoded in the genome of human.
Short Label hPLK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9NYY3 (PLK2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
C26 S-Nitrosylation dbSNO 19483679
K80 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
T298 Phosphorylation Q9NYY3 (PLK2) neXtProt 22100274
S301 Phosphorylation Q9NYY3 (PLK2) neXtProt   PhosphoSitePlus 22100274
S302 Phosphorylation Q9NYY3 (PLK2) neXtProt   PhosphoSitePlus 22100274
S313 Phosphorylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
S324 Phosphorylation Q9NYY3 (PLK2) neXtProt 22100274
K366 Methylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
S389 Phosphorylation Q9NYY3 (PLK2) neXtProt 22100274
K390 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
T416 Phosphorylation Q9NYY3 (PLK2) neXtProt 22100274
K438 Ubiquitination PhosphoSitePlus
S500 Phosphorylation Q9NYY3 (PLK2) neXtProt 22100274
S591 Phosphorylation Q9NYY3 (PLK2) neXtProt   PhosphoSitePlus 22100274
T593 Phosphorylation Q9NYY3 (PLK2) neXtProt   PhosphoSitePlus 22100274

Q9NYY3 (PLK2) as PTM Enzyme

Substrate Site Score Source PMID
O15350 (TP73) S48 PhosphoSitePlus 26640387, 26625870
O43166 (SIPA1L1) S1349 neXtProt 21382555
O43852 (CALU) S44 PhosphoSitePlus 22828320
O43852 (CALU) T60 PhosphoSitePlus 22828320
O43852 (CALU) T196 PhosphoSitePlus 22828320
P06748 (NPM1) S4 neXtProt   PhosphoSitePlus   Signor 15190079, 20352051
P37840 (SNCA) S129 neXtProt   PhosphoSitePlus   Signor 25657004, 19004816, 19889641, ...20356833, 26719332
P53350 (PLK1) S137 neXtProt   PhosphoSitePlus 19706541
P62258 (YWHAE) T208 PhosphoSitePlus 22828320
Q16143 (SNCB) S118 neXtProt   PhosphoSitePlus   Signor 19889641
Q969H0 (FBXW7) S25 PhosphoSitePlus 22399798
Q969H0 (FBXW7) S176 PhosphoSitePlus   Signor 22399798
Q969H0 (FBXW7) S349 PhosphoSitePlus 22399798
Q9HC77 (CENPJ) S589 neXtProt   PhosphoSitePlus   Signor 20531387
Q9HC77 (CENPJ) S595 neXtProt   PhosphoSitePlus   Signor 20531387
Q9NYY3 (PLK2) T298 neXtProt 22100274
Q9NYY3 (PLK2) S301 neXtProt 22100274
Q9NYY3 (PLK2) S302 neXtProt 22100274
Q9NYY3 (PLK2) S324 neXtProt 22100274
Q9NYY3 (PLK2) S389 neXtProt 22100274
Q9NYY3 (PLK2) T416 neXtProt 22100274
Q9NYY3 (PLK2) S500 neXtProt 22100274
Q9NYY3 (PLK2) S591 neXtProt 22100274
Q9NYY3 (PLK2) T593 neXtProt 22100274

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T6 S6 Biomuta DOID:3963 / thyroid carcinoma [ tcga ]
K95 T95 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K129 R129 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T239 M239 Biomuta DOID:363 / uterine cancer [ tcga ]
T298 K298 Biomuta DOID:3571 / liver cancer [ icgc ]
T298 A298 Biomuta DOID:10534 / stomach cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S301 F301 Biomuta DOID:1324 / lung cancer [ cosmic ]
T593 S593 Biomuta DOID:10534 / stomach cancer [ cosmic ]