Protein Information

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UniProt AC / UniProt ID Q9NYV4 / CDK12_HUMAN
Protein Name Cyclin-dependent kinase 12
Gene Name Name: CDK12
Synonyms:CRK7,CRKRS,KIAA0904;
Organism Homo sapiens (Human)

PRO ID PR:Q9NYV4
DAG View
PRO Name cyclin-dependent kinase 12 (human)
Definition A cyclin-dependent kinase 12 that is encoded in the genome of human.
Short Label hCDK12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NYV4 (CDK12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S32 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T57 Phosphorylation PhosphoSitePlus   UniProt 18691976
Y73 Phosphorylation PhosphoSitePlus   UniProt 18691976
S77 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S78 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S80 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T82 Phosphorylation PhosphoSitePlus
S84 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S148 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K203 Acetylation PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
S215 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S220 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S236 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
S238 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S249 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 20068231
S251 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S253 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S265 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
S274 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...17192257
S276 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...17192257
Y279 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S293 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S301 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S303 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692
Y305 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus   UniProt 21406692
S311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y313 Phosphorylation PhosphoSitePlus
S316 Phosphorylation phospho.ELM 18669648
S318 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y319 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S320 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S325 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y327 Phosphorylation PhosphoSitePlus
R329 Methylation PhosphoSitePlus
R330 Methylation PhosphoSitePlus
R331 Methylation PhosphoSitePlus
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
S333 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S334 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
S338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
S341 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S343 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S345 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S349 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S382 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 17192257, ...17081983
S385 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 17192257, 18669648, ...19690332, 20068231
S393 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S394 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231
S420 Phosphorylation PhosphoSitePlus   UniProt 19369195
K421 Ubiquitination PhosphoSitePlus
S423 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 19369195, 15302935, 17192257, 18669648, 24275569, 20068231, 17081983
S434 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
R449 Methylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
K504 Acetylation PhosphoSitePlus
K509 Acetylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
T520 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
T592 O-Glycosylation GlyGen   PhosphoSitePlus 27114449, 28314751, 31637018, ...30059200, 21740066, 29249144, 20305658, 32119511, 29351928, 22661428, 29237092, 20068230
S593 O-Glycosylation GlyGen 27114449, 28314751, 31637018, ...30059200, 21740066, 29249144, 20305658, 32119511, 29351928, 22661428, 29237092, 20068230
S597 O-Glycosylation GlyGen   PhosphoSitePlus 27114449, 28314751, 31637018, ...30059200, 21740066, 29249144, 20305658, 32119511, 29351928, 22661428, 29237092, 20068230
S601 O-Glycosylation GlyGen 27114449, 28314751, 31637018, ...30059200, 21740066, 29249144, 20305658, 32119511, 29351928, 22661428, 29237092, 20068230
S608 O-Glycosylation GlyGen 27114449, 28314751, 31637018, ...30059200, 21740066, 29249144, 20305658, 32119511, 29351928, 22661428, 29237092, 20068230
S614 Phosphorylation PhosphoSitePlus   UniProt 23186163
S644 Phosphorylation PhosphoSitePlus
S681 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19369195, 17192257, 18669648, 24275569, 19690332, 20068231
S685 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 17081983, ...19369195, 17192257, 18669648, 24275569, 19690332, 20068231
T692 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...19369195, 15302935, 18669648
K747 Ubiquitination PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
T770 Phosphorylation PhosphoSitePlus
K796 Acetylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
Y849 Phosphorylation PhosphoSitePlus
K861 Ubiquitination PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
S889 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y892 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T893 Phosphorylation P50613 (CDK7) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17192257, ...24662513, 18669648, 25712099, 20068231
S954 Phosphorylation PhosphoSitePlus
K973 Acetylation PhosphoSitePlus
T1002 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
K1021 Ubiquitination PhosphoSitePlus
K1027 Ubiquitination PhosphoSitePlus
K1045 Ubiquitination PhosphoSitePlus
S1053 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S1063 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
T1070 Phosphorylation PhosphoSitePlus
T1071 Phosphorylation PhosphoSitePlus
S1075 Phosphorylation PhosphoSitePlus
T1076 Phosphorylation PhosphoSitePlus
S1082 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1083 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 20068231
S1226 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
T1244 Phosphorylation PhosphoSitePlus   UniProt 19690332
T1246 Phosphorylation PhosphoSitePlus
T1375 Phosphorylation PhosphoSitePlus
S1387 Phosphorylation PhosphoSitePlus
R1404 Methylation PhosphoSitePlus
T1448 O-Glycosylation GlyGen 27114449, 28314751, 31637018, ...30059200, 21740066, 29249144, 20305658, 32119511, 29351928, 22661428, 29237092, 20068230
K1470 Acetylation PhosphoSitePlus
R1473 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 18691976
S18 Phosphorylation HPRD 18691976
S24 Phosphorylation HPRD 18691976, 20068231
S25 Phosphorylation HPRD 18691976
S29 Phosphorylation HPRD 18691976
S32 Phosphorylation HPRD 18691976
T57 Phosphorylation HPRD 18691976, 17081983
S62 Phosphorylation HPRD 17081983
T65 Phosphorylation HPRD 17081983
Y73 Phosphorylation HPRD 18691976, 17081983, 20068231
S77 Phosphorylation HPRD 18691976, 17081983, 20068231, ...18452278
S78 Phosphorylation HPRD 18691976, 17081983, 20068231, ...18452278
S80 Phosphorylation HPRD 18691976, 17081983, 20068231, ...18452278
T82 Phosphorylation HPRD 20068231, 18452278
S84 Phosphorylation HPRD 18691976, 17081983, 20068231
S215 Phosphorylation HPRD 15302935
S228 Phosphorylation HPRD 18691976
S236 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231, 18452278
S238 Phosphorylation HPRD 18691976, 18452278
S241 Phosphorylation HPRD 18691976
S249 Phosphorylation HPRD 18691976, 15302935, 18452278, ...19651622, 18669648, 20068231
S251 Phosphorylation HPRD 18669648, 18452278
S253 Phosphorylation HPRD 19651622
S265 Phosphorylation HPRD 15302935, 20068231
S274 Phosphorylation Q9NYV4 (CDK12) HPRD 19651622, 18691976, 17192257, ...20230923
S276 Phosphorylation Q9NYV4 (CDK12) HPRD 17322306, 18691976, 19651622, ...20230923
S291 Phosphorylation HPRD 18691976
S293 Phosphorylation HPRD 18691976, 15302935
Y295 Phosphorylation HPRD 18767875
S296 Phosphorylation HPRD 18767875
S301 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S303 Phosphorylation HPRD 19651622, 18691976, 18669648, ...15302935, 20068231
S316 Phosphorylation HPRD 18669648
S318 Phosphorylation HPRD 18669648
Y319 Phosphorylation HPRD 19651622, 18669648
S320 Phosphorylation HPRD 18767875, 18669648
S323 Phosphorylation HPRD 19651622, 18691976, 18669648, ...18767875
S325 Phosphorylation HPRD 19651622, 18691976, 18669648, ...18767875
Y327 Phosphorylation HPRD 18767875
S332 Phosphorylation HPRD 18691976, 17081983, 18767875, ...19651622, 18669648, 20068231
S333 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S334 Phosphorylation HPRD 18691976, 16964243, 18767875, ...19651622, 18669648, 20068231, 17081983
S338 Phosphorylation HPRD 19651622, 17081983
S341 Phosphorylation HPRD 18691976, 18669648
S343 Phosphorylation HPRD 18691976, 18669648
S345 Phosphorylation HPRD 18669648
S355 Phosphorylation HPRD 19651622
S357 Phosphorylation HPRD 19651622
S359 Phosphorylation HPRD 19651622
S379 Phosphorylation HPRD 18691976, 17081983
S382 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S383 Phosphorylation Q9NYV4 (CDK12) HPRD 18691976, 20230923, 17192257, ...19651622, 18669648, 20068231
S385 Phosphorylation Q9NYV4 (CDK12) HPRD 18691976, 20230923, 17192257, ...19651622, 18669648, 20068231
S393 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S394 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S400 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 20068231
S420 Phosphorylation HPRD 20068231
S423 Phosphorylation HPRD 18691976, 18767875, 15302935, ...19664995, 18452278, 19651622, 18669648, 20068231
S503 Phosphorylation HPRD 18452278
T514 Phosphorylation HPRD 18691976, 18452278
S681 Phosphorylation Q9NYV4 (CDK12) HPRD 19413330, 18691976, 19664995, ...17192257, 18452278, 19651622, 18669648, 20068231
S685 Phosphorylation Q9NYV4 (CDK12) HPRD 19413330, 18691976, 19664995, ...17192257, 18452278, 19651622, 18669648, 20068231
T692 Phosphorylation HPRD 19413330, 18691976, 16964243, ...15302935, 19664994, 19664995, 18669648
T770 Phosphorylation HPRD 20068231
S889 Phosphorylation HPRD 19651622
Y892 Phosphorylation HPRD 18669648
T893 Phosphorylation Q9NYV4 (CDK12) HPRD 18691976, 18767875, 19664995, ...18452278, 19651622, 17322306, 18669648, 20068231
S1075 Phosphorylation HPRD 18691976
T1076 Phosphorylation HPRD 19413330
S1082 Phosphorylation HPRD 19413330, 18691976, 18669648, ...17081983, 20068231
S1083 Phosphorylation HPRD 19413330, 18691976, 18491316, ...18767875, 15302935, 19007248, 19664995, 19651622, 19664994, 18669648, 20068231
S1236 Phosphorylation HPRD 17081983
T1244 Phosphorylation HPRD 18691976
T1246 Phosphorylation HPRD 17081983
T1363 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S332 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S1236 Phosphorylation PhosphoSitePlus
T1244 Phosphorylation PhosphoSitePlus
T1246 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S334 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus


Q9NYV4 (CDK12) as PTM Enzyme



Substrate Site Score Source PMID
P24928 (POLR2A) S1616 PhosphoSitePlus 26748711, 23249733, 25561469, ...22012619
P24928 (POLR2A) S1619 PhosphoSitePlus 26748711, 24662513, 25561469
P24928 (POLR2A) S1861 Signor 22012619
P24928 (POLR2A) S1868 Signor 22012619
P24928 (POLR2A) S1875 Signor 22012619
P24928 (POLR2A) S1878 Signor 22012619
P24928 (POLR2A) S1882 Signor 22012619
P24928 (POLR2A) S1889 Signor 22012619
P24928 (POLR2A) S1896 Signor 22012619
P24928 (POLR2A) S1910 Signor 22012619
P24928 (POLR2A) S1917 Signor 22012619
P24928 (POLR2A) S1924 Signor 22012619
P24928 (POLR2A) S1931 Signor 22012619
P24928 (POLR2A) S1941 Signor 22012619
P24928 (POLR2A) S1948 Signor 22012619
Q9NYV4-1 (CDK12) S274 HPRD 19651622, 18691976, 17192257, ...20230923
Q9NYV4-1 (CDK12) S276 HPRD 17322306, 18691976, 19651622, ...20230923
Q9NYV4-1 (CDK12) S383 HPRD 18691976, 20230923, 17192257, ...19651622, 18669648, 20068231
Q9NYV4-1 (CDK12) S385 HPRD 18691976, 20230923, 17192257, ...19651622, 18669648, 20068231
Q9NYV4-1 (CDK12) S681 HPRD 19413330, 18691976, 19664995, ...17192257, 18452278, 19651622, 18669648, 20068231
Q9NYV4-1 (CDK12) S685 HPRD 19413330, 18691976, 19664995, ...17192257, 18452278, 19651622, 18669648, 20068231
Q9NYV4-1 (CDK12) T893 HPRD 18691976, 18767875, 19664995, ...18452278, 19651622, 17322306, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 C29 Biomuta DOID:1324 / lung cancer [ tcga ]
S30 F30 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T82 I82 Biomuta DOID:363 / uterine cancer [ tcga ]
S148 L148 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S154 L154 Biomuta DOID:3070 / malignant glioma [ tcga ]
K211 T211 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S231 Y231 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S238 L238 Biomuta DOID:1324 / lung cancer [ cosmic ]
S256 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S265 R265 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S276 T276 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S283 L283 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
Y285 C285 Biomuta DOID:5041 / esophageal cancer [ icgc ]
Y295 C295 Biomuta DOID:3571 / liver cancer [ tcga ]
Y305 H305 Biomuta DOID:263 / kidney cancer [ cosmic ]
S316 N316 Biomuta DOID:1909 / melanoma [ cosmic ]
S323 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S323 L323 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S325 N325 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y327 C327 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S334 C334 Biomuta DOID:0070003 / blastoma [ cosmic ]
S338 G338 Biomuta DOID:1612 / breast cancer [ cosmic ]
S341 Y341 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S363 * Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K421 N421 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R449 T449 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S503 C503 Biomuta DOID:10534 / stomach cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
S521 L521 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ]
S593 Y593 Biomuta DOID:1324 / lung cancer [ tcga ]
S614 C614 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T692 P692 Biomuta DOID:1612 / breast cancer [ tcga ]
K756 N756 Biomuta DOID:4362 / cervical cancer [ tcga ]
S838 L838 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc ]
K861 M861 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S889 C889 Biomuta DOID:1324 / lung cancer [ tcga ]
T893 R893 Biomuta DOID:1324 / lung cancer [ tcga ]
S1063 P1063 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1066 P1066 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
S1066 Y1066 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1236 N1236 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R1404 C1404 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R1404 H1404 Biomuta DOID:9256 / colorectal cancer [ tcga ]