iPTMnet Report Q9NYV4 CDK12

Protein Information

UniProt AC / UniProt ID	Q9NYV4 / CDK12_HUMAN
Protein Name	Cyclin-dependent kinase 12
Gene Name	Name: CDK12 Synonyms:CRK7,CRKRS,KIAA0904;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9NYV4 DAG View
PRO Name	cyclin-dependent kinase 12 (human)
Definition	A cyclin-dependent kinase 12 that is encoded in the genome of human.
Short Label	hCDK12
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9NYV4 (CDK12) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S14 S18 S24 S25 S29 S30 S32 T57 Y73 S77 S78 S80 T82 S84 S148 S154 T158 Y161 S176 S177 K203 T206 K211 S215 S220 S222 S228 S230 S231 S236 S238 S241 S249 S251 S253 T255 S256 S257 S261 S265 S274 S276 Y279 S283 Y285 S287 S288 S291 S293 S301 S303 Y305 S306 S310 S311 S312 Y313 S316 S318 Y319 S320 S323 S325 Y327 R329 R330 R331 S332 S333 S334 S338 S341 S343 S345 S349 S355 S357 S359 Y362 S363 S382 S383 S385 S393 S394 S400 S420 K421 S423 S434 S440 R449 S503 K504 K509 T514 T520 S521 S579 T592 S593 S596 S597 S601 S608 S614 S644 S681 S685 T692 K747 K756 K764 T770 K796 K803 S838 Y849 K861 S886 S889 Y892 T893 S954 K973 T1002 S1006 K1021 K1027 K1045 S1053 S1063 S1066 T1070 T1071 S1075 T1076 S1082 S1083 S1226 S1232 T1244 T1246 T1363 T1375 S1387 R1404 T1447 T1448 S1451 S1453 S1465 S1466 K1470 R1473	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all GlyGen IEDB PhosphoSitePlus RLIMS-P UniProt phospho.ELM	PMID
S14	Phosphorylation		score1	PhosphoSitePlus
S18	Phosphorylation		score1	PhosphoSitePlus
S24	Phosphorylation		score1	PhosphoSitePlus
S25	Phosphorylation		score1	PhosphoSitePlus
S29	Phosphorylation		score1	PhosphoSitePlus
S30	Phosphorylation		score1	PhosphoSitePlus
S32	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	15302935
T57	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976
Y73	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976
S77	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17081983
S78	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17081983
S80	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17081983
T82	Phosphorylation		score1	PhosphoSitePlus
S84	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17081983
S148	Phosphorylation		score1	PhosphoSitePlus
S154	Phosphorylation		score1	PhosphoSitePlus
T158	Phosphorylation		score1	PhosphoSitePlus
Y161	Phosphorylation		score1	PhosphoSitePlus
S176	Phosphorylation		score1	PhosphoSitePlus
S177	Phosphorylation		score1	PhosphoSitePlus
K203	Acetylation		score1	PhosphoSitePlus
T206	Phosphorylation		score1	PhosphoSitePlus
K211	Acetylation		score1	PhosphoSitePlus
S215	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	15302935
S220	Phosphorylation		score1	PhosphoSitePlus
S222	Phosphorylation		score3	IEDB PhosphoSitePlus	22645359
S228	Phosphorylation		score1	PhosphoSitePlus
S230	Phosphorylation		score1	PhosphoSitePlus
S231	Phosphorylation		score1	PhosphoSitePlus
S236	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 18669648, ...19690332, 20068231
S238	Phosphorylation		score1	PhosphoSitePlus
S241	Phosphorylation		score1	PhosphoSitePlus
S249	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 15302935, ...18669648, 20068231
S251	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S253	Phosphorylation		score1	PhosphoSitePlus
T255	Phosphorylation		score1	PhosphoSitePlus
S256	Phosphorylation		score1	PhosphoSitePlus
S257	Phosphorylation		score1	PhosphoSitePlus
S261	Phosphorylation		score1	PhosphoSitePlus
S265	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 15302935
S274	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 17081983, ...17192257
S276	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 17081983, ...17192257
Y279	Phosphorylation		score1	PhosphoSitePlus
S283	Phosphorylation		score1	PhosphoSitePlus
Y285	Phosphorylation		score1	PhosphoSitePlus
S287	Phosphorylation		score1	PhosphoSitePlus
S288	Phosphorylation		score1	PhosphoSitePlus
S291	Phosphorylation		score1	PhosphoSitePlus
S293	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	15302935
S301	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 21406692
S303	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 15302935, 21406692
Y305	Phosphorylation		score1	PhosphoSitePlus
S306	Phosphorylation		score1	PhosphoSitePlus
S310	Phosphorylation		score2	PhosphoSitePlus UniProt	21406692
S311	Phosphorylation		score1	PhosphoSitePlus
S312	Phosphorylation		score2	PhosphoSitePlus UniProt	21406692
Y313	Phosphorylation		score1	PhosphoSitePlus
S316	Phosphorylation		score1	phospho.ELM	18669648
S318	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
Y319	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S320	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S323	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S325	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
Y327	Phosphorylation		score1	PhosphoSitePlus
R329	Methylation		score1	PhosphoSitePlus
R330	Methylation		score1	PhosphoSitePlus
R331	Methylation		score1	PhosphoSitePlus
S332	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 21406692, 23186163, ...17081983
S333	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 21406692
S334	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 21406692, 23186163, ...17081983
S338	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 17081983
S341	Phosphorylation		score2	IEDB phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 30784271
S343	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S345	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S349	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
S349	Phosphorylation		score1	PhosphoSitePlus
S355	Phosphorylation		score1	PhosphoSitePlus
S357	Phosphorylation		score1	PhosphoSitePlus
S359	Phosphorylation		score1	PhosphoSitePlus
Y362	Phosphorylation		score1	PhosphoSitePlus
S363	Phosphorylation		score1	PhosphoSitePlus
S382	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648, 17081983
S383	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 19690332, 17192257, ...17081983
S385	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	17081983, 17192257, 18669648, ...19690332, 20068231
S393	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648, 17081983
S394	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648, 17081983
S400	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 18669648, 20068231
S420	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
K421	Ubiquitination		score1	PhosphoSitePlus
S423	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 21406692, 23186163, ...16964243, 19369195, 15302935, 17192257, 18669648, 24275569, 20068231, 17081983
S434	Phosphorylation		score1	PhosphoSitePlus
S440	Phosphorylation		score1	PhosphoSitePlus
R449	Methylation		score1	PhosphoSitePlus
S503	Phosphorylation		score1	PhosphoSitePlus
K504	Acetylation		score1	PhosphoSitePlus
K509	Acetylation		score1	PhosphoSitePlus
T514	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 23186163
T520	Phosphorylation		score1	PhosphoSitePlus
S521	Phosphorylation		score1	PhosphoSitePlus
S579	O-Glycosylation		score2	GlyGen IEDB	28314751
T592	O-Glycosylation		score2	GlyGen PhosphoSitePlus	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 32938750, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
S593	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 32938750, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
S596	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
S597	O-Glycosylation		score2	GlyGen PhosphoSitePlus	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 32938750, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
S601	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
S608	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
S614	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S644	Phosphorylation		score1	PhosphoSitePlus
S681	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 21406692, 23186163, ...17081983, 19369195, 17192257, 18669648, 24275569, 19690332, 20068231
S685	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 21406692, 17081983, ...19369195, 17192257, 18669648, 24275569, 19690332, 20068231
T692	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	19369195, 23186163, 16964243, ...18691976, 15302935, 18669648
K747	Ubiquitination		score1	PhosphoSitePlus
K756	Ubiquitination		score1	PhosphoSitePlus
K764	Ubiquitination		score1	PhosphoSitePlus
T770	Phosphorylation		score1	PhosphoSitePlus
K796	Acetylation		score1	PhosphoSitePlus
K796	Ubiquitination		score1	PhosphoSitePlus
K803	Ubiquitination		score1	PhosphoSitePlus
S838	Phosphorylation		score1	PhosphoSitePlus
Y849	Phosphorylation		score1	PhosphoSitePlus
K861	Ubiquitination		score1	PhosphoSitePlus
S886	Phosphorylation		score1	PhosphoSitePlus
S889	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
Y892	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T893	Phosphorylation	P50613 (CDK7)	score4	IEDB phospho.ELM PhosphoSitePlus RLIMS-P UniProt	21406692, 23186163, 17192257, ...24662513, 18669648, 27869121, 25712099, 20068231
S954	Phosphorylation		score1	PhosphoSitePlus
K973	Acetylation		score1	PhosphoSitePlus
T1002	Phosphorylation		score1	PhosphoSitePlus
S1006	Phosphorylation		score1	PhosphoSitePlus
K1021	Ubiquitination		score1	PhosphoSitePlus
K1027	Ubiquitination		score1	PhosphoSitePlus
K1045	Ubiquitination		score1	PhosphoSitePlus
S1053	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195, 23186163
S1063	Phosphorylation		score1	PhosphoSitePlus
S1066	Phosphorylation		score1	PhosphoSitePlus
T1070	Phosphorylation		score1	PhosphoSitePlus
T1071	Phosphorylation		score1	PhosphoSitePlus
S1075	Phosphorylation		score1	PhosphoSitePlus
T1076	Phosphorylation		score1	PhosphoSitePlus
S1082	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S1083	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 15302935, ...18669648, 20068231
S1226	Phosphorylation		score1	PhosphoSitePlus
S1232	Phosphorylation		score1	PhosphoSitePlus
T1244	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332
T1246	Phosphorylation		score1	PhosphoSitePlus
T1363	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
T1375	Phosphorylation		score1	PhosphoSitePlus
S1387	Phosphorylation		score1	PhosphoSitePlus
R1404	Methylation		score1	PhosphoSitePlus
T1447	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
T1448	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
S1451	O-Glycosylation		score1	GlyGen	34846842
S1453	O-Glycosylation		score1	GlyGen	34846842
S1465	O-Glycosylation		score1	GlyGen	34846842
S1466	O-Glycosylation		score1	GlyGen	28314751, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 27114449, 29249144, 32119511, 31637018, 35132862, 20305658, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 36240223, 20068230
K1470	Acetylation		score1	PhosphoSitePlus
R1473	Methylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S14 S18 S24 S25 S29 S32 T57 S62 T65 Y73 S77 S78 S80 T82 S84 S215 S228 S236 S238 S241 S249 S251 S253 S265 S274 S276 S291 S293 Y295 S296 S301 S303 S316 S318 Y319 S320 S323 S325 Y327 S332 S333 S334 S338 S341 S343 S345 S355 S357 S359 S379 S382 S383 S385 S393 S394 S400 S420 S423 S503 T514 S681 S685 T692 T770 S889 Y892 T893 S1075 T1076 S1082 S1083 S1236 T1244 T1246 T1363	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0	Source Select all HPRD	PMID
S14	Phosphorylation		score0	HPRD	18691976
S18	Phosphorylation		score0	HPRD	18691976
S24	Phosphorylation		score0	HPRD	18691976, 20068231
S25	Phosphorylation		score0	HPRD	18691976
S29	Phosphorylation		score0	HPRD	18691976
S32	Phosphorylation		score0	HPRD	18691976
T57	Phosphorylation		score0	HPRD	18691976, 17081983
S62	Phosphorylation		score0	HPRD	17081983
T65	Phosphorylation		score0	HPRD	17081983
Y73	Phosphorylation		score0	HPRD	18691976, 17081983, 20068231
S77	Phosphorylation		score0	HPRD	18691976, 17081983, 20068231, ...18452278
S78	Phosphorylation		score0	HPRD	18691976, 17081983, 20068231, ...18452278
S80	Phosphorylation		score0	HPRD	18691976, 17081983, 20068231, ...18452278
T82	Phosphorylation		score0	HPRD	20068231, 18452278
S84	Phosphorylation		score0	HPRD	18691976, 17081983, 20068231
S215	Phosphorylation		score0	HPRD	15302935
S228	Phosphorylation		score0	HPRD	18691976
S236	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...20068231, 18452278
S238	Phosphorylation		score0	HPRD	18691976, 18452278
S241	Phosphorylation		score0	HPRD	18691976
S249	Phosphorylation		score0	HPRD	18691976, 15302935, 18452278, ...19651622, 18669648, 20068231
S251	Phosphorylation		score0	HPRD	18669648, 18452278
S253	Phosphorylation		score0	HPRD	19651622
S265	Phosphorylation		score0	HPRD	15302935, 20068231
S274	Phosphorylation	Q9NYV4 (CDK12)	score0	HPRD	19651622, 18691976, 17192257, ...20230923
S276	Phosphorylation	Q9NYV4 (CDK12)	score0	HPRD	17322306, 18691976, 19651622, ...20230923
S291	Phosphorylation		score0	HPRD	18691976
S293	Phosphorylation		score0	HPRD	18691976, 15302935
Y295	Phosphorylation		score0	HPRD	18767875
S296	Phosphorylation		score0	HPRD	18767875
S301	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...20068231
S303	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...15302935, 20068231
S316	Phosphorylation		score0	HPRD	18669648
S318	Phosphorylation		score0	HPRD	18669648
Y319	Phosphorylation		score0	HPRD	19651622, 18669648
S320	Phosphorylation		score0	HPRD	18767875, 18669648
S323	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...18767875
S325	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...18767875
Y327	Phosphorylation		score0	HPRD	18767875
S332	Phosphorylation		score0	HPRD	18691976, 17081983, 18767875, ...19651622, 18669648, 20068231
S333	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...17081983, 20068231
S334	Phosphorylation		score0	HPRD	18691976, 16964243, 18767875, ...19651622, 18669648, 20068231, 17081983
S338	Phosphorylation		score0	HPRD	19651622, 17081983
S341	Phosphorylation		score0	HPRD	18691976, 18669648
S343	Phosphorylation		score0	HPRD	18691976, 18669648
S345	Phosphorylation		score0	HPRD	18669648
S355	Phosphorylation		score0	HPRD	19651622
S357	Phosphorylation		score0	HPRD	19651622
S359	Phosphorylation		score0	HPRD	19651622
S379	Phosphorylation		score0	HPRD	18691976, 17081983
S382	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...17081983, 20068231
S383	Phosphorylation	Q9NYV4 (CDK12)	score0	HPRD	18691976, 20230923, 17192257, ...19651622, 18669648, 20068231
S385	Phosphorylation	Q9NYV4 (CDK12)	score0	HPRD	18691976, 20230923, 17192257, ...19651622, 18669648, 20068231
S393	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...17081983, 20068231
S394	Phosphorylation		score0	HPRD	19651622, 18669648, 17081983, ...20068231
S400	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...17081983, 20068231
S420	Phosphorylation		score0	HPRD	20068231
S423	Phosphorylation		score0	HPRD	18691976, 18767875, 15302935, ...19664995, 18452278, 19651622, 18669648, 20068231
S503	Phosphorylation		score0	HPRD	18452278
T514	Phosphorylation		score0	HPRD	18691976, 18452278
S681	Phosphorylation	Q9NYV4 (CDK12)	score0	HPRD	19413330, 18691976, 19664995, ...17192257, 18452278, 19651622, 18669648, 20068231
S685	Phosphorylation	Q9NYV4 (CDK12)	score0	HPRD	19413330, 18691976, 19664995, ...17192257, 18452278, 19651622, 18669648, 20068231
T692	Phosphorylation		score0	HPRD	19413330, 18691976, 16964243, ...15302935, 19664994, 19664995, 18669648
T770	Phosphorylation		score0	HPRD	20068231
S889	Phosphorylation		score0	HPRD	19651622
Y892	Phosphorylation		score0	HPRD	18669648
T893	Phosphorylation	Q9NYV4 (CDK12)	score0	HPRD	18691976, 18767875, 19664995, ...18452278, 19651622, 17322306, 18669648, 20068231
S1075	Phosphorylation		score0	HPRD	18691976
T1076	Phosphorylation		score0	HPRD	19413330
S1082	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...17081983, 20068231
S1083	Phosphorylation		score0	HPRD	19413330, 18691976, 18491316, ...18767875, 15302935, 19007248, 19664995, 19651622, 19664994, 18669648, 20068231
S1236	Phosphorylation		score0	HPRD	17081983
T1244	Phosphorylation		score0	HPRD	18691976
T1246	Phosphorylation		score0	HPRD	17081983
T1363	Phosphorylation		score0	HPRD	20068231

Search:

Site Select all By amino acid All Serine All Threonine By position S332 S333 S383 S385 S1236 T1244 T1246	PTM Type Select all Phosphorylation	Score Select all 1	Source Select all PhosphoSitePlus
S332	Phosphorylation	score1	PhosphoSitePlus
S333	Phosphorylation	score1	PhosphoSitePlus
S383	Phosphorylation	score1	PhosphoSitePlus
S385	Phosphorylation	score1	PhosphoSitePlus
S1236	Phosphorylation	score1	PhosphoSitePlus
T1244	Phosphorylation	score1	PhosphoSitePlus
T1246	Phosphorylation	score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine By position S334 S338 S341 S343 S345	PTM Type Select all Phosphorylation	Score Select all 1	Source Select all PhosphoSitePlus
S334	Phosphorylation	score1	PhosphoSitePlus
S338	Phosphorylation	score1	PhosphoSitePlus
S341	Phosphorylation	score1	PhosphoSitePlus
S343	Phosphorylation	score1	PhosphoSitePlus
S345	Phosphorylation	score1	PhosphoSitePlus

Q9NYV4 (CDK12) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P24928 (POLR2A) Q13177 (PAK2) Q9NYV4-1 (CDK12)	Site Select all By amino acid All Serine All Threonine By position T134 T169 S274 S276 S383 S385 S681 S685 T893 S1616 S1619 S1861 S1868 S1875 S1878 S1882 S1889 S1896 S1910 S1917 S1924 S1931 S1941 S1948	Score Select all 0 1 3	Source Select all HPRD PhosphoSitePlus Signor	PMID
P24928 (POLR2A)	S1616	score3	PhosphoSitePlus	26748711, 23249733, 25561469, ...22012619
P24928 (POLR2A)	S1619	score3	PhosphoSitePlus	26748711, 24662513, 25561469
P24928 (POLR2A)	S1861	score1	Signor	22012619
P24928 (POLR2A)	S1868	score1	Signor	22012619
P24928 (POLR2A)	S1875	score1	Signor	22012619
P24928 (POLR2A)	S1878	score1	Signor	22012619
P24928 (POLR2A)	S1882	score1	Signor	22012619
P24928 (POLR2A)	S1889	score1	Signor	22012619
P24928 (POLR2A)	S1896	score1	Signor	22012619
P24928 (POLR2A)	S1910	score1	Signor	22012619
P24928 (POLR2A)	S1917	score1	Signor	22012619
P24928 (POLR2A)	S1924	score1	Signor	22012619
P24928 (POLR2A)	S1931	score1	Signor	22012619
P24928 (POLR2A)	S1941	score1	Signor	22012619
P24928 (POLR2A)	S1948	score1	Signor	22012619
Q13177 (PAK2)	T134	score1	Signor	32483448
Q13177 (PAK2)	T169	score1	Signor	32483448
Q9NYV4-1 (CDK12)	S274	score0	HPRD	19651622, 18691976, 17192257, ...20230923
Q9NYV4-1 (CDK12)	S276	score0	HPRD	17322306, 18691976, 19651622, ...20230923
Q9NYV4-1 (CDK12)	S383	score0	HPRD	18691976, 20230923, 17192257, ...19651622, 18669648, 20068231
Q9NYV4-1 (CDK12)	S385	score0	HPRD	18691976, 20230923, 17192257, ...19651622, 18669648, 20068231
Q9NYV4-1 (CDK12)	S681	score0	HPRD	19413330, 18691976, 19664995, ...17192257, 18452278, 19651622, 18669648, 20068231
Q9NYV4-1 (CDK12)	S685	score0	HPRD	19413330, 18691976, 19664995, ...17192257, 18452278, 19651622, 18669648, 20068231
Q9NYV4-1 (CDK12)	T893	score0	HPRD	18691976, 18767875, 19664995, ...18452278, 19651622, 17322306, 18669648, 20068231

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S24 S25 S29 S30 S62 T82 S84 S148 S154 K211 S228 S231 S238 S241 S256 S265 S276 S283 Y285 S291 Y295 S303 Y305 S310 S312 S316 Y319 S323 S325 Y327 R329 R331 S332 S334 S338 S341 S345 S357 S363 S394 S420 K421 S423 S440 R449 S503 K504 S521 S593 S601 S608 S614 S644 S681 K756 K803 S838 K861 S889 Y892 T893 S954 T1002 S1053 S1063 S1066 S1082 S1232 S1236 S1387 R1404 R1473	Variant Select all * A1002 A241 C1404 C228 C231 C285 C29 C295 C327 C334 C503 C614 C889 C892 C954 D357 F1066 F228 F30 F332 F420 F608 F62 F681 F84 G325 G338 H305 I265 I82 L148 L154 L238 L283 L323 L329 L423 L521 L838 M861 N1082 N1232 N1236 N1387 N29 N303 N316 N325 N394 N421 N756 N803 N861 P1063 P1066 P84 Q1473 Q329 Q756 R1387 R265 R312 R345 R893 T1053 T211 T276 T449 T644 T756 V503 W256 W331 Y1066 Y231 Y341 Y593 Y601	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1793 / pancreatic cancer [ icgc ] DOID:2394 / ovarian cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, tcga ] DOID:2531 / hematologic cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] [ cosmic ]
S24	*	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S25	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S29	N29	Biomuta	[ cosmic ]
S29	C29	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S30	F30	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S62	F62	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T82	I82	Biomuta	DOID:363 / uterine cancer [ icgc ]
S84	P84	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S84	F84	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S148	*	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S148	L148	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S154	L154	Biomuta	DOID:1319 / brain cancer [ icgc ]
K211	T211	Biomuta	DOID:1793 / pancreatic cancer [ icgc ]
S228	C228	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S228	F228	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S231	Y231	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S231	C231	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S238	*	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S238	L238	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S241	A241	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S256	*	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S256	W256	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S265	R265	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S265	I265	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S276	T276	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S283	L283	Biomuta	DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S283	*	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
Y285	C285	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
Y285	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S291	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
Y295	C295	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S303	N303	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
Y305	H305	Biomuta	DOID:263 / kidney cancer [ cosmic ]
S310	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S312	R312	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S316	N316	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y319	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S323	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S323	L323	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S325	N325	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S325	G325	Biomuta	DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y327	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
Y327	C327	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
R329	Q329	Biomuta	DOID:4159 / skin cancer [ cosmic ]
R329	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
R329	L329	Biomuta	DOID:1612 / breast cancer [ cosmic ]
R331	W331	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S332	F332	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
S334	C334	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S338	G338	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S341	Y341	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
S345	R345	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S357	D357	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S363	*	Biomuta	DOID:2394 / ovarian cancer [ cosmic, tcga ]
S394	N394	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S420	F420	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K421	N421	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S423	L423	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S440	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
R449	T449	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S503	V503	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S503	C503	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K504	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S521	L521	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
S593	Y593	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S601	Y601	Biomuta	DOID:363 / uterine cancer [ cosmic ]
S608	F608	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S614	C614	Biomuta	DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S644	T644	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S681	F681	Biomuta	DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K756	T756	Biomuta	DOID:1612 / breast cancer [ cosmic ]
K756	Q756	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
K756	N756	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
K803	N803	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S838	L838	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K861	M861	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
K861	N861	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S889	C889	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
Y892	C892	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T893	R893	Biomuta	DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S954	C954	Biomuta	DOID:2394 / ovarian cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
T1002	A1002	Biomuta	[ cosmic ]
S1053	T1053	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S1063	P1063	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
S1066	F1066	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S1066	P1066	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
S1066	Y1066	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1082	N1082	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S1232	N1232	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S1236	N1236	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S1387	R1387	Biomuta	DOID:1319 / brain cancer [ cosmic ]
S1387	N1387	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
R1404	C1404	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R1473	Q1473	Biomuta	DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9NYV4 (CDK12)

Protein Information

Interactive Sequence View

Q9NYV4 (CDK12) as Substrate

Q9NYV4 (CDK12) as PTM Enzyme

PTM sites affected in variants