iPTMnet Report for Q9NYT0 (PLEK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NYT0 / PLEK2_HUMAN
Protein Name Pleckstrin-2
Gene Name Name: PLEK2
Organism Homo sapiens (Human)

PRO ID PR:Q9NYT0
DAG View
PRO Name pleckstrin-2 (human)
Definition A pleckstrin-2 that is encoded in the genome of human.
Short Label hPLEK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NYT0 (PLEK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T32 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus   UniProt 23186163
S128 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
K234 Sumoylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
Y333 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K339 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S120 F120 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S128 G128 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T326 N326 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y333 S333 Biomuta DOID:9256 / colorectal cancer [ cosmic ]