iPTMnet Report for Q9NYL2 (MAP3K20)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NYL2 / M3K20_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 20
Gene Name Name: MAP3K20
Synonyms:MLK7;ORFNames:HCCS4;
Organism Homo sapiens (Human)

PRO ID PR:Q9NYL2
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 20 (human)
Definition A mitogen-activated protein kinase kinase kinase 20 that is encoded in the genome of human.
Short Label hMAP3K20
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NYL2 (MAP3K20) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19369195, 22223895
S2 Phosphorylation PhosphoSitePlus   UniProt 32289254
S2 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
S3 Phosphorylation PhosphoSitePlus   UniProt 32289254
S3 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
S7 Phosphorylation PhosphoSitePlus   UniProt 32289254
S7 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
K34 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
Y78 Phosphorylation PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
T161 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 15342622, 26999302
T161 Phosphorylation Q9NYL2 (MAP3K20) PhosphoSitePlus   Signor   UniProt 15342622
T162 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 15342622
T162 Phosphorylation Q9NYL2 (MAP3K20) PhosphoSitePlus   Signor 15342622
S165 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 15342622, 26999302
S165 Phosphorylation Q9NYL2 (MAP3K20) PhosphoSitePlus   Signor   UniProt 15342622
C231 Methylation IEDB 31844290
K248 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
C273 Methylation IEDB 31844290
S275 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S302 Phosphorylation PhosphoSitePlus   UniProt 18691976, 32289254
S302 Phosphorylation Q9NYL2 (MAP3K20) UniProt 18691976
K304 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
W339 Phosphorylation UniProt 18691976, 19369195
K354 Acetylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
K369 Acetylation PhosphoSitePlus
K376 Acetylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
E429 Phosphorylation UniProt 11042189
K434 Phosphorylation UniProt 18691976, 19369195
D454 Phosphorylation UniProt 18691976, 18669648, 19369195
K538 Acetylation PhosphoSitePlus
K544 Acetylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus   UniProt 23186163
S568 Phosphorylation PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
T586 Phosphorylation PhosphoSitePlus   UniProt 32289254
T586 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
S587 Phosphorylation UniProt 32289254
S587 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
S591 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S593 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S599 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S603 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S610 Phosphorylation PhosphoSitePlus
T628 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...19369195
S633 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163, ...19690332
S635 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
S637 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...17192257
T639 Phosphorylation PhosphoSitePlus
S648 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S649 Phosphorylation PhosphoSitePlus   UniProt 23186163, 32289254
S649 Phosphorylation Q9NYL2 (MAP3K20) UniProt 23186163
S654 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus   UniProt 32289254
S660 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
S661 Phosphorylation PhosphoSitePlus
T664 Phosphorylation UniProt 32289254
T664 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
T666 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
R670 Methylation IEDB   PhosphoSitePlus 27503676
Y673 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
R683 Methylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus   UniProt 23186163
S687 Phosphorylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
R693 Methylation PhosphoSitePlus
R695 Methylation PhosphoSitePlus
T704 Phosphorylation PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
R707 Methylation PhosphoSitePlus
R709 Methylation PhosphoSitePlus
K713 Methylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus   UniProt 32289254
S718 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
S720 Phosphorylation PhosphoSitePlus   UniProt 32289254
S720 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
S727 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...18669648, 24275569, 20068231
S733 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163
T742 Phosphorylation UniProt 32289254
T742 Phosphorylation Q9NYL2 (MAP3K20) UniProt 32289254
S757 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
T769 Phosphorylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 19651622, 18691976
S7 Phosphorylation HPRD 19651622
Y120 Phosphorylation HPRD 20068231
S136 Phosphorylation HPRD 20068231
S268 Phosphorylation HPRD 18691976
S275 Phosphorylation HPRD 18691976
S302 Phosphorylation HPRD 18691976
S357 Phosphorylation HPRD 18691976
S568 Phosphorylation HPRD 18767875
S591 Phosphorylation HPRD 18691976
S593 Phosphorylation HPRD 18691976, 18669648
S599 Phosphorylation HPRD 18669648
S603 Phosphorylation HPRD 18669648
T628 Phosphorylation HPRD 18691976, 18669648
S633 Phosphorylation HPRD 17322306, 18691976, 18669648
S635 Phosphorylation HPRD 18691976
S636 Phosphorylation HPRD 18691976, 17192257
S637 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 17322306, 18669648, 19651622
T639 Phosphorylation HPRD 18767875
S648 Phosphorylation HPRD 18767875
T666 Phosphorylation HPRD 18691976
S667 Phosphorylation HPRD 18691976
S687 Phosphorylation HPRD 19651622, 18691976
S691 Phosphorylation HPRD 19651622, 18691976
Y696 Phosphorylation HPRD 18691976
Y715 Phosphorylation HPRD 20068231
S718 Phosphorylation HPRD 20068231
S727 Phosphorylation HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
S733 Phosphorylation HPRD 18691976, 18669648
S754 Phosphorylation HPRD 18691976
S781 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 19651622, 18691976
S7 Phosphorylation HPRD 19651622
K116 Acetylation PhosphoSitePlus
Y120 Phosphorylation HPRD 20068231
S136 Phosphorylation HPRD 20068231
S268 Phosphorylation HPRD 18691976
S275 Phosphorylation HPRD 18691976
S302 Phosphorylation HPRD 18691976
K321 Ubiquitination PhosphoSitePlus
S326 Phosphorylation HPRD 18691976
T328 Phosphorylation HPRD   PhosphoSitePlus 18691976
S339 Phosphorylation HPRD   PhosphoSitePlus 18691976
T363 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S434 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
S454 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648


Q9NYL2 (MAP3K20) as PTM Enzyme



Substrate Site Score Source PMID
O96017 (CHEK2) T68 PhosphoSitePlus 15342622
Q9NYL2 (MAP3K20) S2 UniProt 32289254
Q9NYL2 (MAP3K20) S3 UniProt 32289254
Q9NYL2 (MAP3K20) S7 UniProt 32289254
Q9NYL2 (MAP3K20) T161 PhosphoSitePlus   Signor   UniProt 15342622
Q9NYL2 (MAP3K20) T162 PhosphoSitePlus   Signor 15342622
Q9NYL2 (MAP3K20) S165 PhosphoSitePlus   Signor   UniProt 15342622
Q9NYL2 (MAP3K20) S302 UniProt 18691976
Q9NYL2 (MAP3K20) T586 UniProt 32289254
Q9NYL2 (MAP3K20) S587 UniProt 32289254
Q9NYL2 (MAP3K20) S649 UniProt 23186163
Q9NYL2 (MAP3K20) S660 UniProt 32289254
Q9NYL2 (MAP3K20) T664 UniProt 32289254
Q9NYL2 (MAP3K20) S718 UniProt 32289254
Q9NYL2 (MAP3K20) S720 UniProt 32289254
Q9NYL2 (MAP3K20) T742 UniProt 32289254


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S7 F7 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic ]
Y78 C78 Biomuta DOID:3571 / liver cancer [ cosmic ]
S136 L136 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T267 M267 Biomuta DOID:1324 / lung cancer [ cosmic ]
S268 R268 Biomuta DOID:1612 / breast cancer [ cosmic ]
K304 N304 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K316 M316 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K354 R354 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K401 N401 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S567 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S599 L599 Biomuta DOID:3571 / liver cancer [ cosmic ]
S603 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S610 F610 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T639 I639 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S649 F649 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S667 F667 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S668 L668 Biomuta [ cosmic ]
Y673 N673 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S674 L674 Biomuta DOID:1319 / brain cancer [ cosmic ]
R683 C683 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
S685 G685 Biomuta DOID:1324 / lung cancer [ cosmic ]
S690 P690 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y696 C696 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S706 L706 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S727 L727 Biomuta DOID:4159 / skin cancer [ cosmic ]
S733 C733 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T742 I742 Biomuta DOID:363 / uterine cancer [ icgc ]
S764 N764 Biomuta DOID:363 / uterine cancer [ icgc ]
T769 K769 Biomuta DOID:1324 / lung cancer [ cosmic ]