iPTMnet Report for Q9NYK1 (TLR7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NYK1 / TLR7_HUMAN
Protein Name Toll-like receptor 7 precursor
Gene Name Name: TLR7
ORFNames:UNQ248/PRO285;
Organism Homo sapiens (Human)

PRO ID PR:Q9NYK1
DAG View
PRO Name Toll-like receptor 7 (human)
Definition A Toll-like receptor 7 that is encoded in the genome of human.
Short Label hTLR7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NYK1 (TLR7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus
C189 Methylation IEDB 31844290
K293 Ubiquitination PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
N413 N-Glycosylation GlyGen 24190977
N488 N-Glycosylation GlyGen 24190977
S609 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
Y807 Phosphorylation PhosphoSitePlus
Y1024 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 F22 Biomuta DOID:4159 / skin cancer [ cosmic ]
S22 Y22 Biomuta DOID:363 / uterine cancer [ icgc ]
C189 Y189 Biomuta DOID:1319 / brain cancer [ icgc ]
C189 S189 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S359 Y359 Biomuta DOID:3571 / liver cancer [ icgc ]
N413 H413 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
N488 S488 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S609 Y609 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S609 F609 Biomuta DOID:2531 / hematologic cancer [ cosmic ]