iPTMnet Report for Q9NYB0 (TERF2IP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NYB0 / TE2IP_HUMAN
Protein Name Telomeric repeat-binding factor 2-interacting protein 1
Gene Name Name: TERF2IP
Synonyms:DRIP5,RAP1;ORFNames:PP8000;
Organism Homo sapiens (Human)

PRO ID PR:Q9NYB0
DAG View
PRO Name telomeric repeat-binding factor 2-interacting protein 1 (human)
Definition A telomeric repeat-binding factor 2-interacting protein 1 that is encoded in the genome of human.
Short Label hTERF2IP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NYB0 (TERF2IP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
T15 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation HPRD   PhosphoSitePlus 17322306, 20068231
S36 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18847512, 19651622, ...18669648, 20068231
S43 Phosphorylation PhosphoSitePlus   UniProt 23186163
T44 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T52 O-Glycosylation GlyGen 23301498, 26280087, 29351928
T52 Phosphorylation PhosphoSitePlus
C54 S-Nitrosylation dbSNO 24105792
S105 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S154 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18452278, 18669648, 19690332, 20068231
S156 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 20068231, ...18452278
K169 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
Y195 Phosphorylation HPRD   PhosphoSitePlus 19651622
S203 O-Glycosylation GlyGen   IEDB 26280087
S203 Phosphorylation P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 16964243, 21406692, 23186163, ...18212344, 18452278, 24275569, 19690332, 19413330, 18767875, 18847512, 20058876, 17525332, 19651622, 18491316, 17287340, 19664994, 19664995, 17322306, 18669648, 20166139, 19415658, 20068231
S205 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983, 20068231
S206 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17525332, 23186163, ...18077418, 18669648
K208 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T230 Phosphorylation HPRD   PhosphoSitePlus 19651622
Y238 Phosphorylation PhosphoSitePlus
K240 Sumoylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K169 T169 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S176 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S205 F205 Biomuta DOID:4159 / skin cancer [ cosmic ]
S206 F206 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S222 R222 Biomuta DOID:363 / uterine cancer [ icgc ]
Y238 F238 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K252 N252 Biomuta DOID:1324 / lung cancer [ cosmic ]
K384 Q384 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]