iPTMnet Report for Q9NXV6 (CDKN2AIP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NXV6 / CARF_HUMAN
Protein Name CDKN2A-interacting protein
Gene Name Name: CDKN2AIP
Synonyms:CARF;
Organism Homo sapiens (Human)

PRO ID PR:Q9NXV6
DAG View
PRO Name CDKN2A-interacting protein (human)
Definition A CDKN2A-interacting protein that is encoded in the genome of human.
Short Label hCDKN2AIP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NXV6 (CDKN2AIP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S10 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
T110 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation HPRD   PhosphoSitePlus 20068231
T116 Phosphorylation HPRD   PhosphoSitePlus 20068231
T117 Phosphorylation PhosphoSitePlus
S131 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163, 19690332
S132 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T161 O-Glycosylation GlyGen 33465208
S162 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
C178 S-Nitrosylation dbSNO 26338901
S181 Phosphorylation PhosphoSitePlus
K184 Acetylation PhosphoSitePlus
K184 Sumoylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S209 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S209 Phosphorylation PhosphoSitePlus
S211 O-Glycosylation GlyGen 30379171
S211 Phosphorylation PhosphoSitePlus
S212 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S212 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S220 Phosphorylation HPRD   PhosphoSitePlus 18077418
S243 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S277 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S308 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S311 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S312 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
T320 O-Glycosylation GlyGen 33465208
T323 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S324 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S328 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S330 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S331 O-Glycosylation GlyGen 22661428, 33465208
S332 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S337 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S343 Phosphorylation PhosphoSitePlus
T346 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
T346 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
S349 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 32938750, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S350 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S351 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S351 Phosphorylation PhosphoSitePlus
S352 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
T353 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
T355 Phosphorylation PhosphoSitePlus
S356 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S356 Phosphorylation PhosphoSitePlus
T359 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
T359 Phosphorylation PhosphoSitePlus
S360 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S360 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S369 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S369 Phosphorylation HPRD 20068231
S373 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S375 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S375 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
T379 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S382 Phosphorylation PhosphoSitePlus
S385 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S385 Phosphorylation PhosphoSitePlus
S387 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
T388 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S389 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S389 Phosphorylation PhosphoSitePlus   UniProt 23186163
S394 Phosphorylation PhosphoSitePlus
S398 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
K399 Acetylation PhosphoSitePlus
S400 O-Glycosylation GlyGen 30059200
S402 Phosphorylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
S411 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 34725712, 33465208, 32119511, 28411811, 31637018, 32574038, 35132862, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
K412 Ubiquitination PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
Y444 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
C516 Methylation IEDB 31844290
C516 S-Nitrosylation dbSNO 26338901
K518 Ubiquitination PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K99 E99 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T114 I114 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y115 D115 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S132 I132 Biomuta DOID:363 / uterine cancer [ icgc ]
S151 N151 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S152 Y152 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S198 T198 Biomuta DOID:1319 / brain cancer [ cosmic ]
S219 Y219 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S277 P277 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S277 F277 Biomuta DOID:1324 / lung cancer [ cosmic ]
S356 L356 Biomuta DOID:1319 / brain cancer [ cosmic ]
S369 L369 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S377 P377 Biomuta DOID:1319 / brain cancer [ cosmic ]
S382 F382 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K436 R436 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K508 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K508 N508 Biomuta DOID:4159 / skin cancer [ cosmic ]
C516 G516 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S564 L564 Biomuta DOID:3571 / liver cancer [ cosmic ]