iPTMnet Report for Q9NXR1 (NDE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NXR1 / NDE1_HUMAN
Protein Name Nuclear distribution protein nudE homolog 1
Gene Name Name: NDE1
Synonyms:NUDE;
Organism Homo sapiens (Human)

PRO ID PR:Q9NXR1
DAG View
PRO Name nuclear distribution protein nudE homolog 1 (human)
Definition A nuclear distribution protein nudE homolog 1 that is encoded in the genome of human.
Short Label hNDE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NXR1 (NDE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T131 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   Signor 21677187, 33776808
T191 Phosphorylation Q00535 (CDK5) PhosphoSitePlus 26206584
S211 Phosphorylation phospho.ELM   UniProt 18669648, 23186163, 18220336
T215 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 12556484, 18669648, 18220336
T228 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512, 18220336
S231 Phosphorylation phospho.ELM   UniProt 18669648, 23186163, 24275569
S239 Phosphorylation P28482 (MAPK1) phospho.ELM   Signor   UniProt 12556484, 18669648, 23186163
T240 Phosphorylation phospho.ELM 18669648
T243 Phosphorylation phospho.ELM   UniProt 18669648, 20068231
T246 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21529751, 18669648, 29930206, ...20068231
Y279 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S282 Phosphorylation phospho.ELM   UniProt 18669648, 23186163, 16964243, ...20068231
S306 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus 21677187, 17287340
S307 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T308 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus   UniProt 23186163
S320 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S195 Phosphorylation HPRD 20068231
S196 Phosphorylation HPRD 20068231
S211 Phosphorylation HPRD   phospho.ELM 18669648, 20068231, 18220336
S214 Phosphorylation HPRD 20068231
T215 Phosphorylation P28482 (MAPK1) , P06493 (CDK1) HPRD   phospho.ELM 12556484, 18669648, 20068231, ...18220336
T228 Phosphorylation HPRD   phospho.ELM 18669648, 18220336
S231 Phosphorylation HPRD 18669648
S239 Phosphorylation P28482 (MAPK1) , P06493 (CDK1) HPRD 12556484, 18669648, 20068231
T240 Phosphorylation HPRD 18669648, 20068231
T243 Phosphorylation HPRD 18669648, 20068231
T246 Phosphorylation HPRD 18669648, 20068231
Y279 Phosphorylation HPRD 15592455
S282 Phosphorylation HPRD 18691976, 16964243, 19664994, ...19651622, 18669648, 20068231
S291 Phosphorylation HPRD 20068231
S306 Phosphorylation HPRD 19651622, 17287340, 18452278
S307 Phosphorylation HPRD 17287340
S309 Phosphorylation HPRD 18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NXR1 (NDE1) T131 Q9NXR1 (NDE1) unknown eFIP 21677187


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S211 F211 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S214 F214 Biomuta DOID:1324 / lung cancer [ cosmic ]
T215 M215 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
T240 A240 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T246 I246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S291 F291 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S291 Y291 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]