iPTMnet Report for Q9NXH9 (TRMT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NXH9 / TRM1_HUMAN
Protein Name tRNA (guanine(26)-N(2))-dimethyltransferase
Gene Name Name: TRMT1
Organism Homo sapiens (Human)

PRO ID PR:Q9NXH9
DAG View
PRO Name tRNA (guanine(26)-N(2))-dimethyltransferase (human)
Definition An N(2),N(2)-dimethylguanosine tRNA methyltransferase that is encoded in the genome of human.
Short Label hTRMT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NXH9 (TRMT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
C150 Methylation IEDB 31844290
S179 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K371 Acetylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
C457 Methylation IEDB 31844290
S479 Phosphorylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus   UniProt 23186163
R521 Methylation PhosphoSitePlus
R528 Methylation PhosphoSitePlus
R562 Methylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
C606 Methylation IEDB 31844290
K610 Ubiquitination PhosphoSitePlus
S623 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S625 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T628 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S632 Phosphorylation PhosphoSitePlus
C639 S-Nitrosylation dbSNO 26338901
T646 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 20068231
S5 Phosphorylation HPRD 20068231
S9 Phosphorylation HPRD 20068231
T11 Phosphorylation HPRD 20068231
S179 Phosphorylation HPRD 20068231
S186 Phosphorylation HPRD 20068231
T488 Phosphorylation HPRD 20068231
S623 Phosphorylation HPRD 18767875, 18669648
S625 Phosphorylation HPRD 18767875, 18669648, 20068231
T628 Phosphorylation HPRD 18669648, 20068231
T646 Phosphorylation HPRD 19413330, 18669648, 16964243, ...20068231, 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 W4 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S5 F5 Biomuta DOID:3277 / thymus cancer [ cosmic ]
K105 N105 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S120 L120 Biomuta DOID:4159 / skin cancer [ cosmic ]
S179 Y179 Biomuta DOID:4159 / skin cancer [ cosmic ]
S179 F179 Biomuta DOID:363 / uterine cancer [ icgc ]
S186 A186 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K283 N283 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T488 M488 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S514 L514 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R521 C521 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]
R521 H521 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R562 W562 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]