iPTMnet Report for Q9NXG6 (P4HTM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NXG6 / P4HTM_HUMAN
Protein Name Transmembrane prolyl 4-hydroxylase
Gene Name Name: P4HTM
Synonyms:PH4;
Organism Homo sapiens (Human)

PRO ID PR:Q9NXG6
DAG View
PRO Name transmembrane prolyl 4-hydroxylase (human)
Definition A transmembrane prolyl 4-hydroxylase that is encoded in the genome of human.
Short Label hP4HTM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NXG6 (P4HTM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C56 Methylation IEDB 31844290
T107 O-Glycosylation GlyGen 25813380
K118 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
C156 Methylation IEDB 31844290
T176 O-Glycosylation GlyGen 30459171
K265 Ubiquitination PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
N348 N-Glycosylation GlyGen 23090970, 24190977
C357 Methylation IEDB 31844290
T361 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C56 Y56 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S269 T269 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
C357 G357 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]