iPTMnet Report for Q9NXE4 (SMPD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NXE4 / NSMA3_HUMAN
Protein Name Sphingomyelin phosphodiesterase 4
Gene Name Name: SMPD4
Synonyms:KIAA1418,SKNY;
Organism Homo sapiens (Human)

PRO ID PR:Q9NXE4
DAG View
PRO Name sphingomyelin phosphodiesterase 4 (human)
Definition A sphingomyelin phosphodiesterase 4 that is encoded in the genome of human.
Short Label hSMPD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NXE4 (SMPD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S169 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
Y172 Phosphorylation PhosphoSitePlus
T260 Phosphorylation HPRD   PhosphoSitePlus 20068231
S267 Phosphorylation HPRD 20068231
Y268 Phosphorylation PhosphoSitePlus
T273 Phosphorylation HPRD   PhosphoSitePlus 20068231
K277 Ubiquitination PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S336 Phosphorylation HPRD 18691976
K384 Ubiquitination PhosphoSitePlus
S389 Phosphorylation HPRD 19007248, 20068231
S391 Phosphorylation HPRD 18691976
K453 Ubiquitination PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
R490 Methylation PhosphoSitePlus
K500 Acetylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K580 Acetylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
T680 Phosphorylation PhosphoSitePlus
T685 Phosphorylation PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
T708 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
S792 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19007248, ...20068231, 17924679
Site PTM Type PTM Enzyme Score Source PMID
S169 Phosphorylation HPRD 18691976, 18669648, 20068231
T260 Phosphorylation HPRD 20068231
S267 Phosphorylation HPRD 20068231
T273 Phosphorylation HPRD 20068231
S360 Phosphorylation HPRD 19007248, 20068231
S362 Phosphorylation HPRD 18691976
T679 Phosphorylation HPRD 18691976
S763 Phosphorylation HPRD 18691976, 19007248, 20068231, ...17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T273 I273 Biomuta DOID:363 / uterine cancer [ icgc ]
K277 Q277 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S336 C336 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S551 N551 Biomuta DOID:4159 / skin cancer [ cosmic ]
K568 N568 Biomuta DOID:1324 / lung cancer [ cosmic ]
T679 M679 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T680 S680 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K693 E693 Biomuta DOID:4159 / skin cancer [ cosmic ]
K693 N693 Biomuta DOID:1324 / lung cancer [ cosmic ]
T708 M708 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S763 I763 Biomuta DOID:1324 / lung cancer [ cosmic ]
S792 I792 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]