iPTMnet Report for Q9NX74 (DUS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NX74 / DUS2L_HUMAN
Protein Name tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Gene Name Name: DUS2
Synonyms:DUS2L;
Organism Homo sapiens (Human)

PRO ID PR:Q9NX74
DAG View
PRO Name tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (human)
Definition A tRNA-dihydrouridine synthase 2-like that is encoded in the genome of human.
Short Label hDUS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NX74 (DUS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 20068231
Y10 Phosphorylation HPRD 20068231
T24 Phosphorylation HPRD 20068231
K118 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
T175 Phosphorylation HPRD   PhosphoSitePlus 19413330
T234 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
C311 Methylation IEDB 31844290
K337 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
S445 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S447 Phosphorylation HPRD 20068231
K477 Ubiquitination PhosphoSitePlus
S484 Phosphorylation HPRD   PhosphoSitePlus 20068231
S488 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17322306, ...18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 G5 Biomuta DOID:1612 / breast cancer [ icgc ]
S121 F121 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C311 F311 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]