Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NWZ3 / IRAK4_HUMAN
Protein Name Interleukin-1 receptor-associated kinase 4
Gene Name Name: IRAK4
Organism Homo sapiens (Human)

PRO ID PR:Q9NWZ3
DAG View
PRO Name interleukin-1 receptor-associated kinase 4 (human)
Definition An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of human.
Short Label hIRAK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NWZ3 (IRAK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K3 Acetylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
T6 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17141195
S8 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus   RLIMS-P 17141195, 27876844
K33 Ubiquitination PhosphoSitePlus
K34 Acetylation PhosphoSitePlus   UniProt 19608861
S114 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17141195
K115 Ubiquitination PhosphoSitePlus
S150 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17141195
S151 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17141195
S152 Phosphorylation Q9NWZ3 (IRAK4) phospho.ELM   PhosphoSitePlus 18669648, 17141195
S157 Phosphorylation PhosphoSitePlus
T208 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17141195
T209 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17141195
K313 Ubiquitination PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
T342 Phosphorylation Q9NWZ3 (IRAK4) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17312103, 25034608, 17141195, ...24567333
T345 Phosphorylation Q9NWZ3 (IRAK4) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17312103, 17141195, 25034608, ...17161373, 24567333
S346 Phosphorylation Q9NWZ3 (IRAK4) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17312103, 17141195, 25034608, ...17161373, 24567333
T352 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 24567333
K400 Sumoylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation HPRD 18691976
S150 Phosphorylation HPRD 18691976
S151 Phosphorylation HPRD 18691976
S152 Phosphorylation HPRD 18691976, 18669648, 20068231
T342 Phosphorylation PRO 17141195
T345 Phosphorylation PRO 17141195
S346 Phosphorylation PRO 17141195


Q9NWZ3 (IRAK4) as PTM Enzyme



Substrate Site Score Source PMID
P14598 (NCF1) T133 PhosphoSitePlus   Signor 17217339
P14598 (NCF1) T138 PhosphoSitePlus 17217339
P14598 (NCF1) T153 PhosphoSitePlus 17217339
P14598 (NCF1) S288 PhosphoSitePlus   Signor 17217339
P14598 (NCF1) S320 PhosphoSitePlus   Signor 17217339
P14598 (NCF1) S345 PhosphoSitePlus   Signor 17217339
P14598 (NCF1) S348 PhosphoSitePlus 17217339
P14598 (NCF1) T356 PhosphoSitePlus   Signor 17217339
P14598 (NCF1) S359 PhosphoSitePlus 17217339
P14598 (NCF1) S370 PhosphoSitePlus 17217339
P51617-4 (IRAK1) S376 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 11960013, 12538665
P51617-1 (IRAK1) T387 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 11960013, 12538665
P58753 (TIRAP) T28 neXtProt 20400509
Q96FA3 (PELI1) S70 PhosphoSitePlus 19264966
Q96FA3 (PELI1) S76 PhosphoSitePlus 19264966
Q96FA3 (PELI1) S78 PhosphoSitePlus 19264966
Q96FA3 (PELI1) T80 PhosphoSitePlus 19264966
Q96FA3 (PELI1) S82 PhosphoSitePlus 19264966
Q96FA3 (PELI1) T86 PhosphoSitePlus 19264966
Q96FA3 (PELI1) T127 PhosphoSitePlus 19264966
Q96FA3 (PELI1) T288 PhosphoSitePlus 19264966
Q96FA3 (PELI1) S293 PhosphoSitePlus 19264966
Q9NWZ3 (IRAK4) T6 PhosphoSitePlus 17141195
Q9NWZ3 (IRAK4) S8 PhosphoSitePlus 17141195
Q9NWZ3 (IRAK4) S114 PhosphoSitePlus 17141195
Q9NWZ3 (IRAK4) S150 PhosphoSitePlus 17141195
Q9NWZ3 (IRAK4) S151 PhosphoSitePlus 17141195
Q9NWZ3 (IRAK4) S152 PhosphoSitePlus 17141195
Q9NWZ3 (IRAK4) T208 PhosphoSitePlus 17141195
Q9NWZ3 (IRAK4) T209 PhosphoSitePlus 17141195
Q9NWZ3 (IRAK4) T342 neXtProt   PhosphoSitePlus   Signor 17141195, 24567333
Q9NWZ3 (IRAK4) T345 neXtProt   PhosphoSitePlus   Signor 17141195, 24567333
Q9NWZ3 (IRAK4) S346 neXtProt   PhosphoSitePlus   Signor 17141195, 24567333
Q9NWZ3 (IRAK4) T352 PhosphoSitePlus 24567333


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048046 (hIRAK4/Phos:1) pT342,pT345,pS346 PRO
PR:000027191 (hIRAK4/iso:1/Phos:1) pT342,pT345,pS346 PRO 17141195


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027494 (hIRAK1/iso:1/Phos:1) Interaction PR:Q9NWZ3 (hIRAK4) PRO 11960013
PR:000027494 (hIRAK1/iso:1/Phos:1) Interaction PR:Q9NWZ3 (hIRAK4) PRO 11960013
PR:000027494 (hIRAK1/iso:1/Phos:1) Interaction PR:Q9NWZ3 (hIRAK4) PRO 11960013


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K416 N416 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]